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EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.2.2.19physiological function isoform ARH1 is involved in the action by bacterial toxins as well as intumorigenesis. Isoform ARH3 participates in the degradation of poly-(ADP-ribose) that is synthesized by poly-(ADP-ribose) polymerase 1 in response to oxidative stress-induced DNA damage. Isoform ARH1 is involved in estrogen-stimulated tumorigenesis. Isoform ARH3 is involved in the regulation of parthanatos (PARP1-dependent cell death) 731708
Display the word mapDisplay the reaction diagram Show all sequences 3.2.2.19physiological function protein-reversible ADP-ribosylation is an important posttranslational modification used to control enzymatic and protein activity in different biological systems. This modification regulates nitrogenase activity in several nitrogen-fixing bacterial species. ADP-ribosylation is catalyzed by ADP-ribosyltransferases and is reversed by ADP-ribosylhydrolases 709521
Display the word mapDisplay the reaction diagram Show all sequences 3.2.2.19physiological function the abundance of Adprhl1 protein in tadpole hearts is tightly controlled through a negative regulatory mechanism targeting the 5'-coding sequence of Xenopus adprhl1. Overexpression of full length Adprhl1 variants modified to escape such repression, also disrupts cardiac myofibrillogenesis. Disarrayed myofibrils persist that show extensive branching, with sarcomere division occurring at the actin-Z-disc boundary. Adprhl1-positive cells contain thin actin threads, connected to numerous circular branch points. Recombinant Adprhl1 can localize to stripes adjacent to the Z-disc 750380
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