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3.2.1.124
malfunction
immunization of mice with the kdhAB-deficient mutant provides significant protection against fully virulent Francisella tularensis type A strain Schu S4
-
,
732442
3.2.1.124
malfunction
inactivation of Kdo hydrolase activity produces two phenotypes associated with cationic antimicrobial peptide resistance and O-antigen expression. Kdo hydrolase mutants are highly sensitive to polymyxin B. Production of a fully extended O-antigen is also diminished in a Kdo hydrolase mutant, with a consequent increase in core-lipid A
716260
3.2.1.124
physiological function
Kdo hydrolase plays a role in the maintenance of the bacterial surface. Kdo hydrolase activity modulates O-antigen expression
716260
3.2.1.124
physiological function
the enzyme is involved in the virulence of Francisella tularensis strain LVS
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732442
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