EC Number   |
General Information |
Reference |
|---|
   3.1.4.2 | evolution |
the Arabidopsis GDPD family can be classified into canonical GDPD (AtGDPD1-6) and GDPD-like (AtGDPDL1-7) subfamilies |
716547 |
| 3.1.4.2 | malfunction |
altered phosphatidylcholine metabolism in epithelial ovarian cancer cells leads to 2-4fold increased enzyme activity |
714647 |
| 3.1.4.2 | malfunction |
enzyme-deficient mice exhibit fatty liver and hypomyelination |
752186 |
| 3.1.4.2 | malfunction |
GDE5 expression is reduced in atrophied skeletal muscles in mice and decreasing GDE5 abundance promotes myoblastic differentiation, suggesting that decreased GDE5 expression has a counter-regulatory effect on the progression of skeletal muscleatrophy. Transgenic mice specifically overexpressing GDE5DELTAC471 in skeletal muscle have less type II fiber-rich skeletal muscle mass. Forced expression of full-length GDE5 in cultured myoblasts suppresses myogenic differentiation. Transgenic mice specifically expressing GDE5DELTAC471 in skeletal muscle show less skeletal muscle mass, especially type II fiber-rich muscle |
-, 715534 |
| 3.1.4.2 | malfunction |
GPXPDE1 phosphate deficiency-induced expression is attenuated as photosynthate is deprived, while that of GPX-PDE2 is strikingly enhanced |
716619 |
| 3.1.4.2 | malfunction |
inactivation of the glpQ gene results in reduced growth in medium with glucose as the carbon source, in loss of hydrogen peroxide production when phosphatidylcholine is present, and in a complete loss of cytotoxicity towards HeLa cells, and the glpQ mutant strain exhibited a reduced gliding velocity, overview. The phenotype is reversible par complementation with the wild-type enzyme |
716723 |
| 3.1.4.2 | malfunction |
loss-of-function of the plastid-localized AtGDPD1 leads to a significant decrease in GDPD activity, sn-glycerol 3-phosphate content, phosphate content and seedling growth rate only under phophate starvation compared with the wild-type |
716547 |
| 3.1.4.2 | metabolism |
the enzyme participates in choline metabolism |
752186 |
| 3.1.4.2 | metabolism |
the GDPD-mediated lipid metabolic pathway may be involved in release of phosphate from phospholipids during phosphate starvation |
716547 |
| 3.1.4.2 | more |
a second glycerophosphodiesterase enzyme, MPN566, is catalytically inactive and its deletion does not cause an altered phenotype |
716723 |
