EC Number   |
General Information |
Reference |
|---|
    3.1.3.70 | metabolism |
mannosyl-3-phosphoglycerate phosphatase is the enzyme involved in the second step of the two-step mannosyl-3-phosphoglycerate biosynthetic pathway, most commonly found in (hyper)thermophilic microorganisms |
-, 714274 |
| 3.1.3.70 | metabolism |
the synthesis of MG via mannosyl-3-phosphoglycerate synthase and mannosyl-3-phosphoglycerate phosphatase, the so-called two-step pathway, is the most prevalent route among these organisms. The phosphorylated intermediate mannosyl-3-phosphoglycerate is synthesized by the first enzyme and is subsequently dephosphorylated by the second |
-, 713661 |
| 3.1.3.70 | more |
two distinct enzyme conformations, open and closed, are catalytically relevant: the apo-MpgP is prevalently found in the open state, while the holo-MpgP, in complex with the reaction products, is found in the closed state. Enzyme activation entails a structural rearrangement of Motifs I and IV with concomitant binding of the co-catalytic Mg2+ ion. The closure motion of the C2B domain is subsequently triggered by the anchoring of the phosphoryl group to the co-catalytic metal center, and by Arg167 fixing the mannosyl moiety inside the catalytic pocket |
-, 714274 |
| 3.1.3.70 | physiological function |
mannosyl-3-phosphoglycerate phosphatase is a key mediator in the physiological response to thermal and osmotic stresses, catalyzing the hydrolysis of mannosyl-3-phosphoglycerate into the final product, alpha-mannosylglycerate |
-, 714274 |
| 3.1.3.70 | physiological function |
the enzyme is involved in synthesis of mannosylglycerate |
-, 671435 |
