EC Number   |
General Information |
Reference |
|---|
   3.1.3.106 | malfunction |
suppression of cardiac PAP1 activity/lipin expression may contribute to metabolic dysfunction of the diabetic heart |
707381 |
| 3.1.3.106 | physiological function |
a gene deletion mutant shows decreased lysophosphatidic acid-hydrolyzing activity under phosphate-limiting conditions. Overexpression of PHM8 in yeast results in an increase in the lysophosphatidic acid phosphatase activity in vivo |
-, 754084 |
| 3.1.3.106 | physiological function |
atrial tissue displays PAP1 activity that is 33% lower in those having type 2 diabetes mellitus than in non-diabetic controls |
707381 |
| 3.1.3.106 | physiological function |
bifunctional enzyme displaying C-terminal epoxide hydrolase and N-terminal phosphatase activity. The phosphatase activity represents a 20-60% of lysophosphatidic acid cellular hydrolysis, especially in the cytosol |
729128 |
| 3.1.3.106 | physiological function |
compared to non-diabetic littermates, left ventricular PAP1 activity is 29% lower in 8-months-old Zucker diabetic fatty rats. Left ventricular PAP1 activities are 2.1fold (diabetic fatty rats) and 3.6fold (non-diabetic rats) higher than the respective atrial activities |
707381 |
| 3.1.3.106 | physiological function |
gain-of-function mutations in TP53 downregulate the lysophosphatidic acid phosphatase type 6 (ACP6), leading to upregulation of focal adhesion signaling in an lysophosphatidic acid-dependent manner. Highly expressed in normal fallopian tube epithelium, ACP6 expression is significantly reduced in ovarian cancer tumors and early in situ lesions |
755523 |
| 3.1.3.106 | physiological function |
lysophosphatidate phosphatase plays a significant role in supplying the phosphate during phosphate-deficient conditions |
702463 |
| 3.1.3.106 | physiological function |
the low expression of lipid phosphate phosphatase in many tumor cells makes them hypersensitive to growth promoting and survival signals that are provided by lysophosphatidate, S1P, platelet-derived growth factor and epidermal growth factor. The intracellular actions of the enzyme controls cell migration, division, angiogenesis and chemoresistance. Increased LPP1 expression attenuates lysophosphatidate-induced migration of fibroblasts |
714378 |
