EC Number   |
General Information |
Reference |
|---|
   3.1.21.5 | more |
several models for the mode of action of type III R/M enzymes, detailed overview. 1. Translocation, loop extrusion and collision model. 2. The end reversal model. 3. Transient looping and translocation model from atomic force spectroscopy |
716751 |
| 3.1.21.5 | more |
sliding model for long-range communication on DNA by type III restriction enzymes, distribution of cleavage on head-to-head substrates with end bias, overview |
716397 |
| 3.1.21.5 | physiological function |
characterization of a type III-like restriction system present in clinical Staphylococcus aureus strains that prevents transformation with DNA from other bacterial species. Some methicillin-resistant strains are deficient in this restriction system, and thus are hypersusceptible to the horizontal transfer of DNA from other species, such as Escherichia coli, and could easily acquire a vancomycin-resistance gene from Enterococci, overview |
716751 |
| 3.1.21.5 | physiological function |
DNA cleavage by the type III restriction-modification enzymes requires communication in 1D between two distant indirectly-repeated recognitions sites, resulting in non-specific dsDNA cleavage close to only one of the two sites. The cleavage site selection reflects the dynamics of the preceding stochastic enzyme events that are consistent with bidirectional motion in 1D and DNA cleavage following head-on protein collision. The type III REs exhibits site orientation selectivity |
716397 |
| 3.1.21.5 | physiological function |
dual role for phase variation of the enzyme as a limiter of phage spread and a regulator of a gene expression. The underlying mechanism of action for the alteration in gene expression is not known and does not appear to involve differential methylation of specific recognition sites by Cj0031. Phase variation of Cj0031, as detected during infections in chickens and mice, produces changes in expression of multiple genes that may lead to phenotypic variation and generation of highly differentiated variants with differing capabilities of adaptation to diverse niches |
-, 751730 |
| 3.1.21.5 | physiological function |
Type III RM enzymes are bacterial defense systems that protect the host from invading foreign DNA by nucleolytically cleaving them at specific recognition sites |
751752 |
