EC Number   |
General Information |
Reference |
|---|
   3.1.13.1 | evolution |
RC-RNase 2, a cytotoxic ribonuclease isolated from oocytes of bullfrog Rana catesbeiana, consists of 105 residues linked with 4 disulfide bridges and belongs to the bovine pancreatic ribonuclease (RNase A) superfamily. Among the RC-RNases, the base preference for RNase 2 is UpG but CpG for RCRNase 4, while RC-RNase possesses the base specificity of both UpG and CpG. RC-RNase 2 or 4 has much lower catalytic activity but only 3fold less cytotoxicity than RC-RNase. The differences of side-chain conformations of subsite residues among RNase A, RC-RNase, RC-RNase 4 and rRNase 2 are related to their distinct catalytic activities and base preferences. Chemical shift perturbations of three RC-RNases with various substrate analogues, overview |
749739 |
| 3.1.13.1 | evolution |
RNase II is another 3'-5' hydrolytic exoribonuclease from the RNase II family of exoribonucleases |
750198 |
| 3.1.13.1 | evolution |
RNase R is another 3'-5' hydrolytic exoribonuclease from the RNase II family of exoribonucleases |
750198 |
| 3.1.13.1 | malfunction |
a specific subclass of var genes called upsA are strongly up-regulated in parasites that expressed a defective PfRNase II (C-terminally tagged with the FKBP destabilization domain) compared to wild-type parasites. Different combinations of up to 3 distinct upsA var genes, together with an upsC var gene, were upregulated simultaneously in single parasite clones |
752166 |
| 3.1.13.1 | malfunction |
instead of A-site cleavage, translational pausing in DELTARNase II cells produces transcripts that are truncated +12 and +28 nucleotides downstream of the A-site codon. Deletion of RNase R has little effect on A-site cleavage. Polynucleotide phosphorylase overexpression restores A-site cleavage activity to DELTARNase II cells |
709993 |
| 3.1.13.1 | malfunction |
RNase II thermolability of the rnb500 phenotype is due to the Cys284Tyr mutation within the RNB domain, which abolishes activity by increasing protein kinetic instability at the nonpermissive temperature. In vivo and in vitro investigation of RNase II mutation(s) that confer the rnb500 phenotype |
-, 750548 |
| 3.1.13.1 | malfunction |
RNase R mutants form more biofilms than wild-type cells |
750198 |
| 3.1.13.1 | metabolism |
exoribonuclease-mediated gene silencing, mechanism and a more general regulatory role of ribonucleases in dynamic gene expression in Plasmodium falciparum, overview |
752166 |
| 3.1.13.1 | metabolism |
NF-kappaB-repressing factor phosphorylation regulates transcription elongation via its interactions with 5'->3' exoribonuclease 2 and negative elongation factor. Interleukin-1 has a more drastic effect on NELF-E or XRN2 binding to NKRF than the M1 mutation |
750506 |
| 3.1.13.1 | metabolism |
role for RNase II Lys501 acetylation in modulating cell growth during stress conditions |
751728 |
