EC Number   |
General Information |
Reference |
|---|
   3.1.1.98 | metabolism |
the enzyme removes the palmitoleate modification that is introduced to specific L-serine residues in Wnt proteins by [Wnt protein]-O-palmitoleoyl transferase |
749473 |
| 3.1.1.98 | physiological function |
notum has a role in promoting brain cell numbers during conditions of brain cell loss through tissue remodeling. Notum inhibits wnt11-6 to control brain size in regenerative degrowth and growth. Notum and wnt11-6 antagonism acts in an essentially constitutive process to control brain cell number, potentially through the determination and maintenance of a size set-point for the planarian brain. Notum and wnt11-6 regulate neoblast differentiation to influence brain size. Inhibition of notum does not significantly alter the density of neurons within the brain or average neuronal cell size, indicating that notum is likely to regulate brain:body proportion principally through the regulation of brain cell number |
750384 |
| 3.1.1.98 | physiological function |
Notum hydrolyzes the Wnt palmitoleoylate adduct extracellularly, resulting in inactivated Wnt proteins that form oxidized oligomers incapable of receptor binding. Notum is a Wnt deacylase, and palmitoleoylation is obligatory for the Wnt structure that maintains its active monomeric conformation. Notum is critical for neural and head induction by acting within the presumptive neuroectoderm |
733696 |
| 3.1.1.98 | physiological function |
Notum requires glypicans to suppress Wnt signalling, but does not cleave their glycophosphatidylinositol anchor. Glycosaminoglycan binding sites on Notum probably help to co-localize with Wnt proteins. A large hydrophobic pocket at the active site accommodates palmitoleate |
734779 |
| 3.1.1.98 | physiological function |
Notum1a contributes to a self-regulatory loop that restricts Wnt/betA-catenin signaling. Notum 1a does not interact with Glypican 4, an essential component of the Wnt/planar cell polarity pathway, but plays specific role in the developing vertebrate embryo. In cultured cells, Notum1a inhibits Wnt/beta-catenin signaling |
733700 |
