EC Number   |
General Information |
Reference |
|---|
    3.1.1.24 | malfunction |
PcaJ (beta-ketoadipate:succinyl-coenzyme A transferase) inactivation results in production of 3-oxoadipate from protocatechuic acid. The mutant is a biocatalyst to produce both 3-oxoadipate and muconolactone from a lignin-related aromatic compound, a portion of the produced 3-oxoadipate is converted to levulinic acid through a purification step consisting of extraction from the culture and recrystallization. Muconolactone is purified from the culture of the PcaD-inactivated mutant of KT2440, although the isomeric beta-ketoadipate enol-lactone is supposed to be produced because it is the substrate of PcaD |
-, 751139 |
| 3.1.1.24 | metabolism |
the enzyme is involved in the protocatechuate branch of the 3-oxoadipate pathway, which is a major pathway involved in the catabolism of the aromatic compounds in microbes |
747316 |
| 3.1.1.24 | metabolism |
the enzyme is part of the metabolic pathway for 4-hydroxphenyl and guaiacyl lignin-related aromatic compounds in Pseudomonas putida strain KT2440. 3-Carboxymuconolactone (CML), muconolactone (ML), and betaketoadipate enol-latone (KEL), i.e. 3-oxoadipate, are intermediates observed in the metabolism of lignin-related aromatics |
-, 751139 |
