EC Number   |
General Information |
Reference |
|---|
   2.8.2.21 | malfunction |
enzyme knockout mice do not exhibit a detectable deficiency in short-term lymphocyte homing |
725108 |
| 2.8.2.21 | metabolism |
the enzyme is required for the generation of Siaalpha2->3[6S]beta->4[6S]GlcNAc or a closely related structure in lymph node high endothelial venules. The enzyme does does not contribute to L-selectin ligand expression or lymphocyte homing |
725108 |
| 2.8.2.21 | physiological function |
keratan sulfate (KS) is a carbohydrate side chain covalently attached to extracellular proteoglycans. KS is composed of disaccharide units of 6-sulfated N-acetylglucosamine (GlcNAc) and galactose. GlcNAc6ST3 is a major sulfotransferase for the R-10G-positive KS in the adult mouse brain. GlcNAc-6-O-sulfotransferase (GlcNAc6ST) 1 encoded by Chst5 is an enzyme necessary for the synthesis of GlcNAc-6-sulfated KS chains which are required for neuronal plasticity in the visual cortex of the mouse brain during the critical period, but not in adulthood. GlcNAc-6-sulfated KS is recognized by the R-10G anti-KS antibody, of which the minimum epitope structure is Galbeta1-4GlcNAc(6S)beta1-3Galbeta1-4GlcNAc(6S), and distributes diffusely in neuropils and presents densely in close proximity to the perineuronal region of the perineuronal net (PNN)-positive neurons in the adult visual cortex. GlcNAc6ST3, which has been discovered as an intestinal GlcNAc6ST encoded by Chst5, is a major brain KS sulfotransferase expressed in oligodendrocytes in adulthood. An isoform of the protein-tyrosine phosphatase PTPRZ is also a R-10G-reactive KS proteoglycan. GlcNAc6ST3 may play a role in synthesis of a component of PNN in the adult brain, and the KS-modified isoform of PTPRZ encoded by Ptprz1 might be an extracellular molecule associated with PNNs |
-, 762461 |
| 2.8.2.21 | physiological function |
KS6ST transfers sulfate to the C-6 of Gal of LacNAc on glycoproteins and is responsible for the generation of a Langerin ligands. Langerin plays roles in the first line defense against pathogens and in Birbeck granule formation in Langerhans cells, vLangerin is categorized as a C-type lectin. It recognizes pathogenic fungi, such as Candida sp. and Malassezia sp., expressing heavily mannosylated glycans, Langerin recognizes 6'-sulfo-LacNAc as a preferred, glycan ligand, overview |
704699 |
| 2.8.2.21 | physiological function |
the enzyme is essential for C-6 sulfation of galactose within keratin sulfate in early postnatal brains |
738784 |
