EC Number   |
General Information |
Reference |
|---|
    2.8.2.17 | malfunction |
C6ST-1 activity and C6S production are upregulated in human glioma tissues, when compared to normal brain tissue, and the extent of upregulation positively correlates with glioma malignancy. Inhibition of expression of the two CS synthetic enzymes chondroitin 4-O-sulfotransferase-1 (C4ST-1/CHST11, EC 2.8.2.5) and chondroitin 6-O-sulfotransferase-1 (C6ST-1/CHST3) suppress cell viability, migration and invasion, reduce MMP-2 and MMP-9 expression, and reduce N-cadherin expression, but increase E-cadherin levels. Clinicopathological features, overview |
761061 |
| 2.8.2.17 | malfunction |
deficiency of CHST3 is associated with a phenotype of severe chondrodysplasia with progressive spinal involvement |
701607 |
| 2.8.2.17 | malfunction |
Omani-type spondyloepiphyseal dysplasia with cardiac involvement caused by a missense mutation in CHST3 |
703280 |
| 2.8.2.17 | physiological function |
key molecules promoting migration and invasion exist in the extracellular matrix, and include chondroitin 4-sulfate (C4S) and chondroitin 6-sulfate (C6S), functionally important carbohydrate chains of chondroitin sulfate proteoglycans that participate in regulating cancer development. The C4S- and C6S-enhanced epithelial-tomesenchymal transition and expression of MMP-2 occur via activation of the PI3K/AKT signaling pathway, known to be involved in promoting cell migration and invasion. C4S and C6S increase the numbers of living glioma cells and promote proliferation, they promote colony formation of glioma cells, phenotypes, overview |
761061 |
| 2.8.2.17 | physiological function |
overexpression of chondroitin 6-sulfotransferase-1 selectively decreases aggrecan, a major chondroitin sulfate proteoglycans in perineuronal nets, in the aged brain without affecting other perineuronal net components |
739172 |
