EC Number |
General Information |
Reference |
---|
2.7.8.33 | evolution |
the enzyme is a member of the polyprenyl-phosphate N-acetylhexosamine 1-phosphate transferase, P2HPT, superfamily |
-, 737788 |
2.7.8.33 | metabolism |
the enzyme is involved in the biosynthetic pathway of peptidoglycan and teichoic acid in Bacillus subtilis strain 168, overview |
-, 738596 |
2.7.8.33 | metabolism |
WecA catalyzes the first membrane step of the biosynthesis of many cell wall polymers such as the O-antigen, teichoic acids and arabinogalactan |
-, 737788 |
2.7.8.33 | physiological function |
enzyme WecA, catalyzes the transfer of the phospho-GlcNAc moiety of UDP-N-acetylglucosamine onto the same lipid carrier, leading to the formation of N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol that is essential for the synthesis of various bacterial cell envelope components. Undecaprenyl diphosphoryl-N-acetylglucosamine (lipid intermediate I) is a ubiquitous compound in all kingdoms of life. the enzyme is involved in the initiation of enterobacterial common antigen biosynthesis |
-, 737788 |
2.7.8.33 | physiological function |
strains lacking transcription regulator component CpxAR or WecA are more susceptible to these stresses than the wild-type, but the complemented strains show phenotypes similar to those of the wild-type. Mice infected with strains lacking CpxAR or WecA activity exhibit lower mortality and bacterial loads in the lung than those infected with the wild-type or complemented strains |
761146 |