EC Number   |
General Information |
Reference |
|---|
    2.7.8.2 | evolution |
the enzyme belongs to the CEPT subfamily |
738578 |
| 2.7.8.2 | malfunction |
inhibition of the CPT activity reduces phospholipid synthesis and results in accumulation of CPT substrates. Reduction of phosphatidylcholine, e.g. by bacterial infection, results in apoptosis |
737738 |
| 2.7.8.2 | malfunction |
reduction of phosphatidylcholine, e.g. by bacterial infection, results in apoptosis |
737738 |
| 2.7.8.2 | malfunction |
very low levels of hydroxy fatty acid are detected when FAH12 (fatty acid hydroxylase) is expressed in seeds of the Arabidopsis rod1 mutant, which contains a lesion in PDCT. A castor PDCT enzyme encoded by the RcROD1 gene increases hydroxy fatty acid levels when coexpressed with FAH12 (fatty acid hydroxylase) |
726223 |
| 2.7.8.2 | metabolism |
CPT catalyzes the final step in the synthesis of phosphatidylcholine via the Kennedy pathway by the transfer of phosphocholine from CDP-choline to 1,2-diacyl-sn-glycerol. The CDP-choline and CDP-ethanolamine pathways are separate routes of phospholipid biosynthesis in mammalian cells, although the CEPT is probably a participant in both pathways |
737738 |
| 2.7.8.2 | metabolism |
CPT catalyzes the final step in the synthesis of phosphatidylcholine via the Kennedy pathway by the transfer of phosphocholine from CDP-choline to 1,2-diacyl-sn-glycerol. The CDP-choline and CDP-ethanolamine pathways are separate routes of phospholipid biosynthesis in mammalian cells, although the CEPT is probably a participant in both pathways. Molecular regulation of the CDP-choline pathway, DNA synthesis and phosphatidylcholine synthesis are not linked, overview. The CDP-choline pathway of phosphatidylcholine synthesis is essential in proliferating cells. The phosphatidylcholine pool is dynamic and the amount of PtdCho represents a balance between synthesis and degradation. phosphatidylcholine and other phospholipids are synthesized in the G2/M phase, rather than S phase. Physiological role of the CDP-choline pathway, overview |
737738 |
| 2.7.8.2 | metabolism |
CPT is a key enzyme in the metabolism of oil in soybean seeds, the enzyme is involved in lipid biosynthesis in soybean seeds and is important for triacylglycerol biosynthesis, together with lysophosphatidylcholine acyltransferase, EC 2.3.1.23. diacylglycerol can also be converted to triacylglycerol by acylation at position 3 of the glycerol molecule in a reaction catalyzed by diacylglycerol acyltransferase, EC 2.3.1.20 |
738332 |
| 2.7.8.2 | metabolism |
the CDP-choline and CDP-ethanolamine pathways are separate routes of phospholipid biosynthesis in mammalian cells, although the CEPT is probably a participant in both pathways. The CPT activity responsible for the synthesis of platelet-activating factor (PAF) is different from those responsible for PtdCho synthesis on the basis of the enzyme's sensitivity to dithiothreitol. Molecular regulation of the CDP-choline pathway, overview. The CDP-choline pathway of phosphatidylcholine synthesis is essential in proliferating cells. The phosphatidylcholine pool is dynamic and the amount of PtdCho represents a balance between synthesis and degradation. Physiological role of the CDP-choline pathway, overview |
737738 |
| 2.7.8.2 | physiological function |
CEPT1 is important for phosphatidylethanolamine formation from fatty acids such as 32:2, 32:1, 34:2, and 34:1, i.e. reaction of EC 2.7.8.1. Brefeldin A treatment does not significantly affect the levels of the different phosphatidylethanolamine species. CEPT1 greatly prefers diacylglycerols 16:0-18:1 to other acceptors |
761663 |
| 2.7.8.2 | physiological function |
cholinephosphotransferase is involved in glycoglycerophospholipid biosynthesis |
-, 703334 |
