EC Number   |
General Information |
Reference |
|---|
    2.7.8.1 | evolution |
the enzyme belongs to the CEPT subfamily |
738578 |
| 2.7.8.1 | malfunction |
reduction of phosphatidylcholine, e.g. by bacterial infection, results in apoptosis |
737738 |
| 2.7.8.1 | metabolism |
the CDP-choline and CDP-ethanolamine pathways are separate routes of phospholipid biosynthesis in mammalian cells, although the CEPT is probably a participant in both pathways. Physiological role of the CDP-choline pathway, overview |
737738 |
| 2.7.8.1 | physiological function |
CEPT1 is important for phosphatidylethanolamine formation from fatty acids such as 32:2, 32:1, 34:2, and 34:1. Brefeldin A treatment does not significantly affect the levels of the different phosphatidylethanolamine species. CEPT1 greatly prefers diacylglycerols 16:0-18:1 to other acceptors |
761663 |
| 2.7.8.1 | physiological function |
endothelial cells of mice carrying a conditional endothelial cell-specific deletion of Cept1 demonstrate decreased proliferation, migration, and tubule formation, and mice carrying the conditional deletion have reduced perfusion and angiogenesis in ischemic hind-limbs. Peripheral ischemic recovery and PPARalpha signaling is further compromised by Streptozotocin-induced diabetes, and ameliorated by feeding fenofibrate |
760955 |
| 2.7.8.1 | physiological function |
EPT1 is important for the de novo biosynthesis of 1-alkenyl-2-acyl-glycerophosphoethanolamine. EPT1 also contributed to the synthesis of phosphatidylethanolamine species containing the fatty acids 36:1, 36:4, 38:5, 38:4, 38:3, 40:6, 40:5, and 40:4. EPT1 prefers 1-alkyl-2-acyl-glycerol 16-20:4 over 1,2-diacylglycerol 18:0-20:4 over 1,2-diacylglycerol 16:0-18:1 and 1-alkyl-2-acyl-glycerol 16-18:1 species as lipid acceptors |
761663 |
| 2.7.8.1 | physiological function |
ethanolamine phosphotransferase-null parasites are largely devoid of plasmenylethanolamine and fully viable in regular medium but fail to proliferate in the absence of fetal bovine serum. They exhibit significant abnormalities in the synthesis and localization of GPI-anchored surface molecules. Ethanolamine phosphotransferase-null mutants also show attenuated virulence in BALB/c mice |
761918 |
| 2.7.8.1 | physiological function |
isoforms AAPT1 and AAPT2 contribute to phosphatidylcholine and phosphatidylethanolamine synthesis and exhibit choline/ethanolamine phosphotransferase-like enzymatic properties. The overexpression of AAPT1 and AAPT2 in Arabidopsis leads to reduced levels of seed triacylglycerol and polyunsaturated fatty acids and decreases seed germination under freezing stress |
762185 |
