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Results 1 - 8 of 8
EC Number General Information Commentary Reference
Display the reaction diagram Show all sequences 2.7.7.71evolution structure analyses reveals that enzyme HddC belongs to the glycosyltransferase A type superfamily members with the signature motif GXGXR for nucleotide binding. Despite of remarkable structural similarity, HddC uses GTP for catalysis instead of CTP and UTP which are used for other major family members, cytidylyltransferase and uridylyltransferase, respectively. The EXXPLGTGGA and L(S/A/G)X(S/G) motifs are probably essential to bind with GTP and a FSFE motif with substrate 760631
Display the reaction diagram Show all sequences 2.7.7.71malfunction blockage of the biosynthesis pathway of GDP-6-deoxy-alpha-D-manno-heptose is lethal or increases antibiotics susceptibility to pathogens 761839
Display the reaction diagram Show all sequences 2.7.7.71metabolism D-glycero-alpha-D-manno-heptose-1-phosphate guanylyltransferase (HddC) is the fourth enzyme synthesizing a building component of lipopolysaccharide (LPS) of Gram-negative bacteria 761308
Display the reaction diagram Show all sequences 2.7.7.71metabolism the enzyme HddC is part of the GDP-D-glycero-alpha-D-manno-heptose biosynthesis pathway, overview 760631
Display the reaction diagram Show all sequences 2.7.7.71metabolism the enzyme is part of the biosynthesis pathway of GDP-6-deoxy-alpha-D-manno-heptose 761839
Display the reaction diagram Show all sequences 2.7.7.71metabolism the GDP-D-alpha-D-heptose biosynthesis pathway (GDP-6dD-heptose pathway) includes D-glycero-alpha-D-manno-heptose-7-phosphate kinase (HddA or WcbL) and D-glycero-alpha-D-manno-heptose-1-phosphate guanylyltransferase (HddC or WcbM) instead of D-glycero-beta-D-manno-heptose-7-phosphate kinase (HldA) and D-glycero-beta-D-manno-heptose-1-phosphate adenylyltransferase (HldC), respectively. Identification of the activity of each enzyme in the GDP-6dD-heptose biosynthesis pathway by MS analysis, overview -, 760405
Display the reaction diagram Show all sequences 2.7.7.71more EXXPLGTGGA and L(S/A/G)X(S/G) motifs are probably essential to bind with GTP and a FSFE motif with substrate. The GXGXR (10GLGTR14 in YpHddC) sequence is the nucleotidyltransferase signature motif participating in interaction with the diphosphate moiety of GTP through their backbone nitrogens. The positively charged surface of this motif is significantly enhanced by the side chain of Arg14 and thus compensates the negative charge of the diphosphate. The side chain of Lys24 also seems to take part in the interaction with the diphosphate 760631
Display the reaction diagram Show all sequences 2.7.7.71more manual docking of GTP with a native YpHddC. Glu80 is found in a unique motif EXEPLGTGGA among approximately five thousand HddC homologues. Therefore, the formation of hydrogen bonds between two oxygens of Glu80 and two nitrogen atoms of GMPPN is suggests to be a major driving force to select and interact with the guanine ring of GMPPN. Glu80 is the key residue to hold GTP in the nucleotide-binding pocket. The active site residues of YpHddC are properly designed to accommodate GTP as a crucial base 761308
Results 1 - 8 of 8