EC Number   |
General Information |
Reference |
|---|
   2.7.7.65 | evolution |
close LIC13137 orthologues, with more than 23% identity, are exclusively found in pathogenic species of the Leptospira genus |
761695 |
| 2.7.7.65 | evolution |
proteins with a conserved C-terminal GGDEF domain act as DGCs, whereas proteins containing EAL or HD-GYP domains act as c-di-GMP-specific phosphodiesterases (PDEs). Vibrio cholerae genome typically encodes 31 proteins with a GGDEF domain |
-, 762429 |
| 2.7.7.65 | evolution |
Pseudomonas putida strain KT2440 has dozens of DGC/PDE-encoding genes in its genome. GcsA homologues are also found in strains of several other Pseudomonas species, including Pseudomonas monteilii strain SB3078, Pseudomonas plecoglossicida strain NyZ12, and Pseudomonas cremoricolorata strain ND07, which share more than 79% amino acid sequence identity with one another, but no GcsA homologues are found in the model organisms Pseudomonas aeruginosa strains PAO1 and PA14, Pseudomonas fluorescens strain Pfl5, and Pseudomonas syringae pv. tomato strain DC3000 |
-, 760994 |
| 2.7.7.65 | evolution |
the GGDEF domain of HsbD has the conserved RxxDmotif (293-296 aa), which forms the allosteric inhibitory site (I-site) of diguanylate cyclases |
-, 762197 |
| 2.7.7.65 | malfunction |
a deletion mutant shows a marked reduction in biofilm formation |
725263 |
| 2.7.7.65 | malfunction |
Borrelia burgdorferi strains that lack Rrp1 or that constitutively produce elevated levels of Rrp1 are generated and analyzed for their ability to infect and transit between mice and Ixodes ticks. Rrp1, and by extension, c-di-GMP, are not required for murine infection, but are required for the successful establishment of a productive population of Borrelia burgdorferi in ticks |
726001 |
| 2.7.7.65 | malfunction |
BpeGReg266 (residues 1-266) and BpeGReg296 (residues 1-296), which only contain the globin and middle domains, can inhibit bacterial motility. The distal residues of the globin domain affect diguanylate cyclase activity, Bpe-GReg may interact with other c-di-GMP-metabolizing proteins to form mixed signaling teams |
-, 762230 |
| 2.7.7.65 | malfunction |
deletion mutant shows a biofilm formation defect, a 4fold better swarming motility and a significant reduction of c-di-GMP levels. No correlation between leveles of c-di-GMP and the observed phenotypic output with regard to swarming motilities and extracellular polysaccharide (EPS) is observed |
725861 |
| 2.7.7.65 | malfunction |
deletion mutant shows a biofilm formation defect, a better swarming motility and a significant reduction of c-di-GMP levels. No correlation between leveles of c-di-GMP and the observed phenotypic output with regard to swarming motilities and extracellular polysaccharide (EPS) is observed |
725861 |
| 2.7.7.65 | malfunction |
deletion of hns or rsmB in the gcpAD418A site-directed mutant restored its Pel production and pelD expression, demonstrating that H-NS and RsmB contribute to the GcpA-dependent regulation of Pel in Dickeya dadantii |
-, 761942 |
