EC Number   |
General Information |
Reference |
|---|
    2.7.7.14 | malfunction |
downregulation of the enzyme leads to reduced phosphatidylethanolamine content in eukaryotic elongation factor 1A. iRNA silencing of Pcyt2 results in significant structural changes in the inner mitochondrial membrane topology defined by a loss of disk-like cristae, showing that the modified mitochondria is the earliest structural change observed after Pcyt2 knockdown. Silencing of Pcyt2 impairs the synthesis of phosphatidylethanolamine and normal cell-cycle progression while oxidative phosphorylation is unaltered |
722415 |
| 2.7.7.14 | malfunction |
inhibition of PE biosynthesis leads to parasite death |
721549 |
| 2.7.7.14 | malfunction |
knockdown of PECT1 by artificial microRNA in the SAM ( pFD::amiR-PECT1) accelerated flowering under inductive and even non-inductive conditions, in which FT transcription is almost absent, and in ft-10 twin sister of ft-1 double mutants under both conditions |
760953 |
| 2.7.7.14 | malfunction |
Pcyt2-yeast mutant is unable to utilize extracellular ethanolamine for phosphatidylethanolamine synthesis |
722415 |
| 2.7.7.14 | metabolism |
important for Kennedy pathway, essential to bloodstream form |
705786 |
| 2.7.7.14 | metabolism |
Phosphatidylethanolamine-Kennedy pathway |
704534 |
| 2.7.7.14 | metabolism |
rate-limiting enzyme in mammalian phosphatidylethanolamine biosynthesis |
761759 |
| 2.7.7.14 | metabolism |
the enzyme catalyzes the rate-limiting step of the PE metabolic pathway in the parasite |
721549 |
| 2.7.7.14 | metabolism |
the enzyme is important and the main regulatory enzyme in de novo production of phosphatidylethanolamine via the CDP-ethanolamine Kennedy pathway, overview |
722415 |
| 2.7.7.14 | metabolism |
the enzyme is important and the main regulatory enzyme in de novo production of phosphatidylethanolamine via the CDP-ethanolamine Kennedy pathway, overview. Pcyt2 gene is a target of liver X receptor |
-, 722415 |
