EC Number   |
General Information |
Reference |
|---|
   2.7.12.1 | evolution |
enzme Yak1 is a member of dual-specificity Tyr phosphorylation-regulated kinases (DYRKs) that are evolutionarily conserved |
-, 740451 |
| 2.7.12.1 | evolution |
enzyme DYRK2 is a member of the dual specificity kinase family, which can phosphorylate both Ser/Thr and Tyr substrates. At least seven DYRK family members have been identified (DYRK1A, DYRK1B, DYRK1C, DYRK2, DYRK3, DYRK4A and DYRK4B) |
741257 |
| 2.7.12.1 | evolution |
enzyme DYRK4 belongs to the dual specificity tyrosine phosphorylation-regulated kinases, DYRKs, a family of conserved protein kinases that play key roles in the regulation of cell differentiation, proliferation, and survival. DYRKs contain a conserved Tyr-Xaa-Tyr motif in the activation loop. Autophosphorylation of a second tyrosine residue within the activation loop is necessary for full DYRK4 kinase activity and is a defining feature of the DYRK family. Family members DYRK1A, DYRK2, and DYRK4 differ in their target recognition sequence, and preference for an arginine residue at position P -3 is a feature of DYRK1A but not of DYRK2 and DYRK4 |
740698 |
| 2.7.12.1 | evolution |
Ser/Thr protein kinases present in Bacillus anthracis genome: Bacillus anthracis has lost key tyrosine kinases and gained novel dual specificity kinases. Dual specificity protein kinases are identified, of which one is similar to the eukaryotic DYRK superfamily. PhrkD and PrkG DSPKs belong to different classes and have different modes of regulation. The mechanism of autophosphorylation and the substrate phosphorylation in PrkG is distinct from that of PrkD and involves Thr residues in addition to Tyr residues |
740700 |
| 2.7.12.1 | evolution |
the enzyme is a member of kinase1 (Yak1) subfamily in the dual-specificity tyrosine phosphorylation-regulated kinase family. The kinase domain of TAR1 also has conserved functional features of the DYRK family, such as an ATP anchor, a phosphate anchor, a catalytic loop, a cation-binding site, and an activation loop |
-, 741205 |
| 2.7.12.1 | malfunction |
a T-DNA insertion mutant of AtSARK shows significantly delayed senescence, while inducible overexpression of AtSARK in Arabidopsis thaliana causes precocious senescence and abnormal floral organ development. phenotypes of transgenic lines, overview |
741199 |
| 2.7.12.1 | malfunction |
Dyrk1A expression is increased in the brain of cystathionine-beta-synthase (CBS)-deficient mice. The murine model of hyperhomocysteinemia shows an activation of extracellular signal-regulated kinase (ERK) pathway. Significant increase of phosphorylated ERK, phosphorylated MAP kinase kinases, and phosphorylated Akt in the brain of CBS-deficient and Dyrk1A-overexpressing mice. Interaction between Dyrk1A and Grb2 is increased in the brain of Dyrk1A transgenic mice, but Dyrk1A overexpression results in decreased interaction of sprouty 2 and Grb2, and in increased receptor tyrosine kinases phosphorylation and activation, overview |
741023 |
| 2.7.12.1 | malfunction |
Dyrk1A participates in the pathogenic mechanisms underlying the mental and other physical symptoms of Down syndrome, alterations in Dyrk1A expression are frequently associated with Down syndrome phenotypes. Knock-out mice are embryonic lethal and heterozygous Dyrk1A mice exhibit decreased neonatal viability, developmental delay, and altered neocortical pyramidal cells |
703132 |
| 2.7.12.1 | malfunction |
dyrk1b antisense morpholino knockdown animals reveal modestly expanded expression of the dorsal axial mesoderm marker gsc while the pan-mesodermal marker bik is largely unaffected, show moderately reduced endodermal markers cas and sox17, and reduced expression of the pharyngeal pouch marker edn1 |
703864 |
| 2.7.12.1 | malfunction |
heterozygous mice for Dyrk1A show marked alterations in traction ability, prehensile reflex and balance, but only present a slight impairment of visuo-spatial memory even though they show a robust decrease of CA1, CA2, CA3 and dentate gyrus cells |
705899 |
