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Results 1 - 10 of 11 > >>
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.8drug target FASTK is an important protein with its valuable implications in various diseases as it serves as a potential drug target 757248
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.8drug target inhibitors of Fas-activated serine/threonine kinase may be exploited as potential anticancer agents 761934
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.8drug target restoration of FASTK expression through genetic approaches might be a promising therapeutic strategy for alcoholic cardiomyopathy (ACM) 762364
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.8malfunction ablating enzyme expression in cultured cells and mice results specifically in loss of ND6 mRNA and reduced complex I activity in vivo 738004
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.8malfunction compared to wild type control, alcohol-related myocardial morphological (hypertrophy, fibrosis and cardiomyocyte apoptosis) and functional (reduced ejection fraction and compromised cardiomyocyte contraction) anomalies are worsened in FASTK deficient mice 762364
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.8malfunction macrophages from FASTK-/- mice exhibit a marked increase in nonopsonic phagocytosis of bacteria. Activity of mitochondrial respiratory complex I is specifically reduced by almost 50% in FASTK-/- macrophages 761639
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.8physiological function the enzyme (FASTK) is a mitochondria-associated nuclear protein that inhibits Fas- and UV-induced apoptosis 757248
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.8physiological function the enzyme (FASTK) is implicated in the apoptotic evasion and, hence, the development of cancer 761934
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.8physiological function the enzyme is a key post-transcriptional regulator of mitochondrial gene expression. Accelerated FASTK mRNA degradation induced by oxidative stress is responsible for the destroyed myocardial mitochondrial gene expression and respiratory function in alcoholic cardiomyopathy 762364
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.8physiological function the mitochondrial isoform is essential for ND6 mRNA biogenesis and complex I activity 738004
Results 1 - 10 of 11 > >>