EC Number   |
General Information |
Reference |
|---|
   2.7.11.23 | drug target |
the highly selective CDK9/P-TEFb inhibitor BAY1143572 shows strong potential as a treatment of adult T-cell leukemia/lymphoma (ATL) |
760779 |
| 2.7.11.23 | evolution |
protistan organisms, such as amoebozoa, kinetoplastids, trichomonads, and diplomonads, which have diverged very early from other eukaryotic lineages, lack repetitive CTD motifs |
740994 |
| 2.7.11.23 | evolution |
the human orthologue of Saccharomyces cerevisiae Ctk1 is one or both of the isozyme pair, hCDK12-hCDK13 |
740509 |
| 2.7.11.23 | evolution |
the metazoan orthologue of Saccharomyces cerevisiae Ctk1 in Drosophila melanogaster is dCDK12 |
740509 |
| 2.7.11.23 | malfunction |
cells lacking CDK12 function are viable and able to proliferate. Antioxidant gene expression is compromised in flies with reduced Cdk12 function, which makes them oxidative stress sensitive, Cdk12 knockdown increases sensitivity to oxidative stress |
741415 |
| 2.7.11.23 | malfunction |
deletion of enzyme complex components in Neurospora leads to high CAT-3 expression level and resistance to H2O2-induced reactive oxygen species stress. Subunit CTK-1 deletion leads to dramatic decreases of SET-2 recruitment and histone H3 K36me3 modification |
-, 760996 |
| 2.7.11.23 | malfunction |
DYRK1A depletion leads to reduced Ser2/Ser5 phosphorylation at its target promoters. The combination of the loss of RNAPII association to the target promoters together with the reduced CTD phosphorylation of the elongating RNAPII is responsible for the reduced expression of the target genes upon DYRK1A depletion |
741006 |
| 2.7.11.23 | malfunction |
enzyme GSK-3 inhibition only prevents CTD hyperphosphorylation triggered by UV but not basal phosphorylation. Enzyme inhibition abrogates both the reduction in RNA polymerase II elongation and changes in AS elicited by UV. GSK-3 inhibition prevents UV-induced apoptosis |
762057 |
| 2.7.11.23 | malfunction |
loss of the enzyme BRD4 is associated with metastatic breast cancer. BRD4 knockdown suppresses global transcription in murine embryonic fibroblasts, overview |
741328 |
| 2.7.11.23 | malfunction |
mutation of Cdk7 phosphorylation site Ser7 in substrate RNAPII CTD is lethal to human cells |
740096 |
