EC Number   |
General Information |
Reference |
|---|
   2.7.11.1 | drug target |
anti-cancer drug resistance restricts the efficacy of chemotherapy in malignant tumors. Casein kinase 2alpha (CK2alpha) is highly expressed in 5-fluorouracil (5FU)-resistant colorectal cancer cells. Casein kinase 2alpha enhances 5-fluorouracil resistance in colorectal cancer cells by inhibiting endoplasmic reticulum stress. 5FU treatment in combination with a CK2alpah inhibitor may exert a synergistic effect against drug-resistant cancer cells |
760350 |
| 2.7.11.1 | drug target |
N-[5-(4-fluorophenyl)-1H-pyrazol-3-yl]-6,7-dimethoxyquinazolin-4-amine is a valuable lead molecules with great potential for CK1delta inhibitor development targeting neurodegenerative disorders and cancer |
760697 |
| 2.7.11.1 | drug target |
possible benefits of applying CKII inhibitors in combination with topo II catalytic inhibitors for effective prevention of mitotic chromosome segregation in tumor cells |
-, 751126 |
| 2.7.11.1 | drug target |
the enzyme is an important target for reversible male contraception |
760895 |
| 2.7.11.1 | evolution |
calcium-dependent protein kinases, which contain both calmodulin-like calcium binding and serine/threonine protein kinase domains, are only present in plants and some protozoans |
-, 721543 |
| 2.7.11.1 | evolution |
casein kinase 1delta (CK1dellta) is an evolutionarily conserved serine/threonine kinase |
743270 |
| 2.7.11.1 | evolution |
casein kinase2 is an evolutionarily conserved serine/threonine protein kinase composed of two catalytic alpha-subunits and two regulatory beta-subunits. Although most of the molecular components responsible for circadian function are not conserved between kingdoms, CK2 is a well-conserved clock component modulating the stability and subcellular localization of essential clock proteins |
-, 723466 |
| 2.7.11.1 | evolution |
CK1 belongs to the CK1 family of serine/threonine kinases, CK1 is evolutionary conserved within eukaryotes |
722389 |
| 2.7.11.1 | evolution |
CKII-mediated phosphorylation of the topo II C-terminal domain appears to be evolutionarily conserved, including in humans |
-, 751126 |
| 2.7.11.1 | evolution |
classification of amino acid residues in the ATP-binding site of the enzyme in diverse Gram-positive bacteria, 20 groups, phylogenetic tree and homology modeling, overview |
723741 |
