    2.7.1.89 | physiological function |
riboswitches are conserved regions within mRNA molecules that bind specific metabolites and regulate gene expression. TPP-riboswitches, which respond to thiamine diophosphate, are involved in the regulation of thiamine metabolism. Thiamine analogues containing a central 1,2,3-triazole group induce repression of thiM-riboswitch dependent gene expression in different Escherichiac coli strains. Triazolethiamine shows concentration-dependent reporter gene repression that is dependent on the presence of thiamine kinase ThiK, whereas the effect of pyrithiamine, a known TPP-riboswitch modulator, is ThiK-independent, overview. ThiK dependency is bypassed by triazolethiamine-derivatives that bear phosphate mimicking and metal-ion chelating moieties |
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