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Results 1 - 10 of 25 > >>
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.78malfunction depletion of Nol9 leads to a severe impairment of ribosome biogenesis. Upon Nol9 knockdown, specific maturation defect at the 5' end of the predominant 5.8S short-form rRNA (5.8SS) occur, possibly due to the Nol9 requirement for 5'>3' exonucleolytic trimming 722115
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.78malfunction knockdown of polynucleotide kinase and aprataxin-like forkhead-associated using siRNA reduces rejoining of two incompatible I-SceI-generated DNA ends by 50% 722727
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.78malfunction mutations lead to a loss of enzyme interaction with the tRNA splicing endonuclease complex, largely reduced pretRNA cleavage activity, and accumulation of linear tRNA introns. The affected individuals develop severe motor-sensory defects, cortical dysgenesis, and microcephaly 729562
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.78malfunction Pnk1 deletion in fission yeast renders cells sensitive to camptothecin 716975
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.78malfunction PNKP depletion in human cells renders cells sensitive to camptothecin. A small molecule inhibitor of PNKP phosphatase activity enhances the sensitivity of cells to IR and camptothecin. Enzyme mutational defects can cause neurological disorders with various symptoms, e.g. a severe neurological autosomal recessive disease characterized by microcephaly, intractable seizures and developmental delay 716975
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.78malfunction polynucleotide kinase Grc3 depletion results in rRNA processing defects 739186
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.78malfunction the lack of CLP1 kinase activity leads to progressive motor neuron loss and accumulation of novel 5' leader-5' exon tRNA fragments 729174
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.78metabolism polynucleotide 5-kinase Nol9 is involved in ribosomal RNA processing 722115
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.78metabolism the enzyme is part of the Pnkp-Hen1 RNA repair pathway, overview 723764
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.78metabolism the enzyme is required for 60S ribosomal particles synthesis 739186
Results 1 - 10 of 25 > >>