EC Number |
General Information |
Reference |
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2.7.1.69 | malfunction |
disruption of glcG gene, encoding enzyme II of the D-glucose phosphoenolpyruvate-dependent phosphotransferase system (PTS), results in greatly improved D-xylose and L-arabinose consumption in the presence of D-glucose. Despite the loss of GlcG, the resulting mutant strain 824glcG ferments D-glucose as efficiently as the parent strain, overview |
721348 |
2.7.1.69 | malfunction |
enhancement of Crp (crp+) in mgsA, pgi, and ptsG mutants, resulting in derivative strains that abolish CCR and induce exclusion mechanisms, allowing the simultaneous consumption of mixtures of sugars with low acetate production |
721383 |
2.7.1.69 | metabolism |
correlation between the activity of the EIICBGlc and the phosphorylation level of the EIIAGlc |
722181 |
2.7.1.69 | metabolism |
the enzyme is involved in the uptake and metabolism of D-glucose and other carbphydrates as part of the phosphoenolpyruvate-carbohydrate phosphotransferase system , PTS, detailed overview. Carbon catabolite repression,CCR, regulation is modulated by the phosphorylation state of EIIAGlc |
721383 |
2.7.1.69 | more |
during growth on fructose, the gene cluster HVO_1495 to HVO_1499, encoding homologues of the five bacterial phosphotransferase system (PTS) components enzyme IIB (EIIB), enzyme I (EI), histidine protein (HPr), EIIA, and EIIC, is highly upregulated as a cotranscript. Functional involvement of this putative PTS and of 1-PFK and FBA in fructose degradation, modeling, overview |
-, 722543 |
2.7.1.69 | more |
membrane-bound EIICGlc and EIIBGlc components conforming the EIICBGlc |
721383 |
2.7.1.69 | more |
the enzyme belongs to the D-glucose phosphoenolpyruvate-dependent phosphotransferase system , PTS, typical PTS contains enzyme I (EI), enzyme II (EII, EC 2.7.1.69) and a histidine-containing protein (HPr) |
721348 |
2.7.1.69 | physiological function |
in Escherichia coli, the phosphoenolpyruvate-carbohydrate phosphotransferase system (PTS), including the enzyme activity of EC 2.7.1.69, is responsible for the transport and phosphorylation of sugars, such as glucose. PTS activity has a crucial role in the global signaling system that controls the preferential consumption of glucose over other carbon sources. When the cell is exposed to carbohydrate mixtures, the PTS prevents the expression of catabolic genes and activity of non-PTS sugars transport systems by carbon catabolite repression, CCR, mechanism, overview. EIIAGlc and EIIBGlc exhibit allosteric regulation on adenylate cyclase, and LacY, a specific transporter for lactose, overview. conditional binding of EIIAGlc to LacY in the presence of lactose avoids waste of this PTS component if the non-PTS substrate is not present in the environment. Regulatory functions of PTS, e.g. on Mlc, overview |
721383 |
2.7.1.69 | physiological function |
In the phosphoenolpyruvate-dependent phosphotransferase system, PTS, system, Enzyme I catalyzes the transfer of the phosphate group from phosphoenolpyruvate to a nitrogen atom of a histidine moiety in a small protein (HPr). In subsequent processes , the appropriate Enzyme II catalyzes the transfer of phosphate from the phosphorylated protein (phospho-HPr) to its specific sugar acceptor, with D-glucose being preferred as substrate compared to sucrose. Regulation of a sucrose PTS in acid-forming clostridia, overview |
-, 702719 |
2.7.1.69 | physiological function |
the glycolytic intermediate glucose-6-phosphate is derived from EII-mediated phosphorylation during D-glucose uptake |
721348 |