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EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.68evolution PIP5K sequences and inferred apicomplexan PIP5K gene tree, overview -, 723333
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.68malfunction downregulation of isoforms PIP5K1alpha and PIP5K1gamma strongly impairs the targeting of HIV-1 Gag polyprotein precursor Pr55Gag to the plasma membrane with a rerouting of the polyprotein within intracellular compartments 759692
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.68malfunction enzyme knockdown affects the recruitment of talin and focal adhesion kinase to the plasma membrane 738165
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.68malfunction enzyme knockdown impairs Akt activation in response to both FBS and ECM protein stimulation 738651
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.68malfunction enzyme knockoout mutants are infertile, phenotypes, overview. Flagella of sperm from isozyme Pip5k1a knockout mutant and even more of Pip5k1a/Pip5k1b double-knockout mutant mice remarkably undergo morphological changes and impairment, whereas Pip5k1b-knockout mutant sperm is morphologically normal. F-actin organization in the seminiferous epithelium is disrupted by the loss of PIP5K1A and PIP5K1B 721782
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.68malfunction enzyme mutants exhibit shorter root hairs than the wild type and remained responsive to phosphate deficiency in root hair elongation 739315
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.68malfunction enzyme silencing impairs CD28-mediated IL-8 and IL-2 transcriptional activation 738787
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.68malfunction isoform PIP5Kalpha knockdown of BV-2 cells significantly suppresses lipoteichoic acid-induced activation of toll-like receptor 2 downstream signaling, including the production of proinflammatory cytokines and phosphorylation of nuclear factor-kappaB, JNK, and p38 MAP kinase. Besides, isoform PIP5Kalpha knockdown inhibits phagocytic uptake of Escherichia coli particles and autophagy-related vesicle formation triggered by lipoteichoic acid 759034
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.68malfunction isozyme PIP5Kalpha knockdown reduces 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate levels and disrupts Toll/IL-1 receptor domain-containing adaptor protein membrane targeting by lipopolysaccharide 722815
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.68malfunction isozyme PIP5Kalpha knockdown reduces 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate levels and disrupts Toll/IL-1 receptor domain-containing adaptor protein membrane targeting by lipopolysaccharide. Isozyme PIP5Kalpha shRNA-15 knockdown cells are less effective inducing iNOS protein expression and nitric oxide production after lipopolysaccharide stimulation overnight and for 24 h, respectively, compared with control cells 722815
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