EC Number   |
General Information |
Reference |
|---|
   2.7.1.23 | drug target |
nicotinamide adenine dinucleotide kinases are attractive for inhibitor development, since they catalyze the phosphorylation of NAD to NADP, which is an essential step of NADP metabolism |
-, 759141 |
| 2.7.1.23 | malfunction |
sll1415-deficient mutant exhibits growth deficiency under photoheterotrophic conditions |
759266 |
| 2.7.1.23 | malfunction |
slr0400-deficient mutant possesses a metabolic profile differed from that of wild-type. It shows metabolic changes in the levels of sugar phosphates (glucose-6-phosphate, ribulose-5-phosphate, 6-phosphogluconate, and fructose-6-phosphate), implying that the upper parts of the glycolytic pathway, the oxidative pentose phosphate pathway, and the Calvin cycle are affected by the disruption of slr0400 |
759266 |
| 2.7.1.23 | malfunction |
the mutant plant osnadk1 in which OsNADK1 is knocked out is a dwarf at the heading stage and has decreased NADP(H)/NAD(H), ascorbic acid (ASA)/dehydroascorbate (DHA) and reduced glutathione (GSH)/oxidized glutathione (GSSG) ratios, which leads to increased oxidation states in the rice cells and sensitivity to drought. Certain stress-related genes show differential expression patterns in osnadk1 under both normal growth and drought-stress conditions compared with wild-type. Compared with the wild-type plants, osnadk1 has a reduced height, smaller flag-leaf dimensions and lower chlorophyll contents at the early filling stage of plant growth |
758975 |
| 2.7.1.23 | malfunction |
the reduction of the NADP(H) level in the sll1415 mutant leads to a significant accumulation of glucose-6-phosphate and a loss of photoheterotrophic growth |
722539 |
| 2.7.1.23 | malfunction |
when cultured under photoheterotrophic growth conditions the sll1415-deficient cells show a growth defect |
759966 |
| 2.7.1.23 | malfunction |
when cultured under photoheterotrophic growth conditions the slr0400-deficient cells show no growth defect |
759966 |
| 2.7.1.23 | metabolism |
NAD kinase is the key enzyme for the de novo biosynthesis of NADP+ and NADPH |
-, 722144 |
| 2.7.1.23 | metabolism |
sll1415 has a significant function in the oxidative pentose phosphate pathway for catabolism of glucose under photoheterotrophic conditions |
759966 |
| 2.7.1.23 | physiological function |
chloroplast NAD kinase 2 has an important role in chlorophyll biosynthesis and protects chloroplasts from oxidative stress |
691390 |
