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Results 1 - 9 of 9
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EC Number General Information Commentary Reference
Display the reaction diagram Show all sequences 2.7.1.174malfunction a Reb1p-binding site mutation abolishes the DGK1-mediated nuclear/endoplasmic reticulum membrane expansion 738595
Display the reaction diagram Show all sequences 2.7.1.174malfunction mutations decrease phosphatidate levels decrease nuclear membrane growth in pah1DELTA cells, the inactivation of Pah1p leads to nuclear growth. A dgk1DLETA strain expressing a mutant DGK1 allele in which residue 177 is changed to alanine does not display any CTP-dependent DAG kinase activity -, 693092
Display the reaction diagram Show all sequences 2.7.1.174metabolism phosphatidate metabolism is a critical factor determining nuclear structure by regulating nuclear membrane biogenesis, DGK1 rescues the lethality of dephosphorylated PAH1 -, 693092
Display the reaction diagram Show all sequences 2.7.1.174metabolism the enzyme in conjunction with Pah1 phosphatidic acid phosphatase controls the levels of phosphatidic acid and diacylglycerol for the synthesis of triacylglycerol and membrane phospholipids, the growth of the nuclear/endoplasmic reticulum membrane, and the formation of lipid droplets -, 761456
Display the reaction diagram Show all sequences 2.7.1.174more Dgk1p contains a CTP transferase domain that is present in the SEC59-encoded dolichol kinase and CDS1-encoded CDP-diacylglycerol synthase enzymes -, 687738
Display the reaction diagram Show all sequences 2.7.1.174more role of phospholipid metabolism in nuclear/ER membrane structure -, 693092
Display the reaction diagram Show all sequences 2.7.1.174physiological function Dgk1p is a unique diacylglycerol kinase that uses CTP, instead of ATP, to generate phosphatidate. The unconventional diacylglycerol kinase regulates phospholipid synthesis and nuclear membrane growth, detailed overview. DGK1 counteracts the activity of PAH1 at the nuclear envelope by controlling phosphatidate levels. Phosphatidate metabolism is a critical factor determining nuclear structure by regulating nuclear membrane biogenesis. DGK1 rescues the lethality of dephosphorylated PAH1 -, 693092
Display the reaction diagram Show all sequences 2.7.1.174physiological function in vivo functions of Dgk1p are specifically due to its diacylglycerol kinase activity. DGK1 counteracts the PAH1-encoded PA phosphatase -, 687738
Display the reaction diagram Show all sequences 2.7.1.174physiological function the enzyme catalyzes the CTP-dependent phosphorylation of diacylglycerol to form phosphatidate, and in conjunction with PAH1-encoded phosphatidate phosphatase, it controls the levels of phosphatidate and diacylglycerol for phospholipid synthesis, membrane growth, and lipid droplet formation. A functional level of diacylglycerol kinase is regulated by the Reb1p transcription factor. Reb1p specifically binds the consensus recognition sequence (CGGGTAA, -166 to -160) in the DGK1 promoter. Diacylglycerol kinase is regulated at the level of transcription. The expression of diacylglycerol kinase is induced by the Reb1p transcription factor, and the resulting activity increase is essential for the enzyme function in phospholipid synthesis. The DGK1-encoded DAG kinase activity causes the accumulation of phosphatidic acid at the nuclear/endoplasmicreticulum membrane when the phospholipid is not hydrolyzed by PAH1-encoded phosphatidic acid phosphatase 738595
Results 1 - 9 of 9
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