EC Number   |
General Information |
Reference |
|---|
   2.7.1.161 | evolution |
prediction of RbkR operator sites and reconstruction of RbkR regulons in 94 archaeal genomes. While the identified RbkR operators show significant variability between archaeal lineages, the conserved core of RbkR regulons includes riboflavin biosynthesis genes, known/predicted vitamin uptake transporters and the rbkR gene. Genetic and sequence comparisons. RbkR regulators in Archaea represent a distinct class of metabolite-sensing transcription factors emerging via fusion between DNA-binding and catalytic domains |
-, 762041 |
| 2.7.1.161 | evolution |
RbkRs genetic and sequence comparisons |
-, 762041 |
| 2.7.1.161 | metabolism |
analysis of the mechanism of the RbkR-mediated transcriptional regulation of riboflavin metabolism in Archaea, overview |
-, 762041 |
| 2.7.1.161 | more |
the FMN binding site comprises residues Tyr115, Phe165, Pro185, Tyr190, and Glu195 |
-, 762041 |
| 2.7.1.161 | physiological function |
riboflavin kinase is an essential enzyme required for synthesis of FMN cofactor from vitamin B2. The bifunctional riboflavin kinase/regulator (RbkR) controls riboflavin biosynthesis and transport genes in major lineages of Crenarchaeota, Euryarchaeota and Thaumarchaeota. RbkR proteins are composed of the riboflavin kinase domain and a DNA-binding winged helix-turn-helix-like domain |
-, 762041 |
| 2.7.1.161 | physiological function |
riboflavin kinase is an essential enzyme required for synthesis of FMN cofactor from vitamin B2. The bifunctional riboflavin kinase/regulator (RbkR) controls riboflavin biosynthesis and transport genes in major lineages of Crenarchaeota, Euryarchaeota and Thaumarchaeota. RbkR proteins are composed of the riboflavin kinase domain and a DNA-binding winged helix-turn-helix-like domain. The riboflavin kinase domain of RbkRs serves not only as an essential function in the flavin biosynthesis but also as a sensor domain ofDNA-binding transcription factor |
-, 762041 |
