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Results 1 - 10 of 27 > >>
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.158evolution differential spatial and temporal expression profiling of gene GmIpk1 and its two homologues Glyma06g03310 and Glyma04g03310 in Glycine max 760240
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.158evolution most residues involved in substrate binding and catalysis are conserved between mammal and plant IP5 2-Ks, but some differences in the inositide P1 and P3 coordination are observed. InmIP5 2-K, additional interactions with P1 are produced through the side chain of Lys173, a residue non-conserved with the plant IP5 2-Ks but absolutely conserved in mammal enzymes, whereas conservative substitutions can be observed in other vertebrates 761460
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.158evolution the amino acid sequence of GmIPK1 shows much similarity with that of Phaseolus vulgaris and Cicer arietinum. It also shows the presence of the characteristic Ins_P5_2-kinase domain required for catalytic activity 761238
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.158malfunction a functional Asp1 kinase domain abolishes invasive growth which is monopolar 723173
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.158malfunction a loss-of-function mutant exhibits disturbed phosphate homeostasis and overaccumulated phosphate as a consequence of increased phosphate uptake activity and root-to-shoot phosphate translocation. The mutant also shows a phosphate deficiency-like root system architecture with reduced primary root and enhanced lateral root growth 739312
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.158malfunction a mutant of inositol pentakisphosphate 2-kinase displays hypersensitivity to arsenate stress and less arsenate uptake when compared to the wild type enzyme 739275
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.158malfunction cells lacking the enzyme display defects in dynein-dependent trafficking pathways including endosomal sorting, vesicle movement and Golgi maintenance -, 737654
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.158malfunction disruption of inositol pentakisphosphate 2-kinase profoundly influences cellular processes 761678
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.158malfunction in contrast to wild-type IPK1, which is able to restore the phosphate content of the ipk1-1 mutant to wild-type level, both kinase-inactive IPK1 forms fail to complement excessive phosphate accumulation and PSR gene activation in ipk1-1. Although both ipk1-1 and itpk1 mutants exhibit decreased levels of InsP6 (phytate) and diphosphoinositol pentakisphosphate (PP-InsP5; InsP7), disruption of another ITPK family enzyme, ITPK4, which correspondingly causes depletion of InsP6 and InsP7, does not display similar phosphate-related phenotypes, which precludes these InsP species from being effectors. Notably, the level of D/L-Ins(3,4,5,6)P4 is concurrently elevated in both ipk1-1 and itpk1 mutants, which demonstrates a specific correlation with the misregulated phosphate phenotypes. The level of D/L-Ins(3,4,5,6)P4 is not responsive to phosphate starvation that instead manifests a shoot-specific increase in the InsP7 level. Misregulation of phosphate homeostasis in ipk1-1 is not caused by defective InsP6-mediated mRNA export. Neither of the kinase-inactive IPK1 mutants K168A and D368A complement the PSR-like RSA phenotypes (i.e. reduced primary root and enhanced lateral root growth) of ipk1-1 mutant. In addition to the decreased InsP6 level, levels of InsP7 and InsP8 are also reduced in ipk1-1 mutants 762144
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.158malfunction urine inositol pentakisphosphate 2-kinase and changes in kidney structure in early diabetic kidney disease in type 1 diabetes. A higher prevalence of detectable urinary inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IPP2K) in type 1 diabetes correlates with early renal function decline. Proximal tubule cells from people with type 1 diabetes and diabetic kidney disease (DKD) express more IPP2K compared with controls. Demographics and clinical characteristics by tertile of baseline urine inositol 1,3,4,5,6-pentakisphosphate 2-kinase/creatinine (IPP2K/Cr), overview 760326
Results 1 - 10 of 27 > >>