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Results 1 - 10 of 27 > >>
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.149evolution PI5P4Kalpha is present in all vertebrates, and a few organisms are missing either beta or gamma. Several key structural differences between the three mammalian PI5P4Ks largely account for their different activities, e.g. a glycine-rich loop supposed to be involved with substrate interaction 721247
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.149evolution two subfamilies of phosphatidylinositol 5-phosphate 4-kinase kinases produce 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate from independent pools of substrates. In addition, type I and II subfamilies of PIPK can localize in different subcellular compartments and are involved in the synthesis of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate in distinct sites within cell 723270
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.149evolution two subfamilies of phosphatidylinositol 5-phosphate 4-kinases produce 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate from independent pools of substrates. In addition, type I and II subfamilies of PIPK can localize in different subcellular compartments and are involved in the synthesis of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate in distinct sites within cell -, 723270
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.149malfunction enzyme depletion enhances the spindle pole accumulation of mitotic centromere-associated kinesin, a microtubule-depolymerizing kinesin, and results in a less stable spindle pole-associated microtubule 759023
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.149malfunction enzyme knockdown leads to severe morphological abnormalities, including midbody winding defects at 48 h post-fertilization 738389
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.149malfunction enzyme-deficient animals show enhanced insulin signaling-dependent phenotypes and are resistant to the metabolic consequences of a high-sugar diet 759027
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.149malfunction flies lacking the enzyme show mislocalization of rhodopsin 1 on expanded endomembranes within the cell body. Enzyme loss is associated with increased clathrin-mediated endocytosis and an enlarged Rab5-positive compartment in cultured Drosophila cells 759534
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.149malfunction isoform PI4Kgamma5 deficiency results in the serrated leaves and accelerated cell division at leaf margin due to the increased auxin level 739399
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.149malfunction long-Term loss of isoform PI5P4Kalpha by gene disruption results in compromised Akt phosphorylation 760061
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.149malfunction loss-of-function mutants in PIP4K show reduced body weight and prolonged larval development 739535
Results 1 - 10 of 27 > >>