EC Number   |
General Information |
Reference |
|---|
   2.7.1.137 | evolution |
PI3K type III is the only type of PI3K identified in plants |
739359 |
| 2.7.1.137 | evolution |
RT0135 contains conserved residues within the catalytic and activation loops of the diverse PI3/PI4 family effectors |
-, 761792 |
| 2.7.1.137 | evolution |
vacuolar protein sorting 34 (Vps34) is a member of the phosphoinositide 3-kinase (PI3K) family of lipid kinases. Vps34 and its functions are highly conserved from yeast to mammals |
760521 |
| 2.7.1.137 | evolution |
vacuolar protein sorting 34 (Vps34) is a member of the phosphoinositide 3-kinase (PI3K) family of lipid kinases. Vps34 and its functions are highly conserved from yeast to mammals. The domain organization of Vps34 and Vps15 are highly conserved between yeast and humans |
760521 |
| 2.7.1.137 | malfunction |
Arabidopsis thaliana pollen development is abnormal in knockout mutants for shared components of two VPS34 complexes (VPS34, VPS15, and ATG6/VPS30) |
761826 |
| 2.7.1.137 | malfunction |
Co-treatment of NB4 cells with either LY294002 to inhibit PI3Ks or PD98059 in order to suppress MEK activity lead to significant reduction of CD11b surface expression during all-trans-retinoic acid, 9-cis-retinoic acid or retinoic acid receptor agonist Ro40-6055 dependent NB4 cells granulocyte differentiation |
709207 |
| 2.7.1.137 | malfunction |
consistent with a regulatory role for Ser90 phosphorylation, induction of autophagy by amino acid starvation is reduced in cells expressing S90A Beclin-1 |
760521 |
| 2.7.1.137 | malfunction |
deletion of a key endosomal trafficking regulator, the class 3 phosphatidylinositol (PtdIns) 3-kinase vacuolar protein sorting 34 (Vps34), in podocytes results in aberrant endosomal membrane morphology and podocyte dysfunction. The vacuolation phenotype in cultured Vps34-deficient podocytes is caused by the absence of a substrate for the Vps34 downstream effector PtdIns 3-phosphate 5-kinase, which phosphorylates Vps34-generated PtdIns(3)P to produce PtdIns (3,5)P2 |
738465 |
| 2.7.1.137 | malfunction |
disruption of PDGFRbeta-PI3K signaling in mice reduces atherosclerosis. Disorganization of the actin cytoskeleton in LRP1-deficient smooth muscle cells is prevented by blocking PI3K activation by PDGFRbeta |
710354 |
| 2.7.1.137 | malfunction |
downregulation of PI3K activity accelerates leaf senescence induced by methyl jasmonate (MeJA) and suppresses the activation of vacuolar H+-ATPase (VATPase) |
762179 |
