EC Number   |
General Information |
Reference |
|---|
    2.7.1.121 | malfunction |
dhaK transposon insertion prevents the growth of Escherichia coli on DHA indicates that DhaKLM reaction is important. Inactivation of dhaKLM is not lethal. Overexpression of the GLD and FSA pathways leads to optimal growth on DHA |
-, 758669 |
| 2.7.1.121 | metabolism |
Escherichia coli can metabolize DHA aerobically through at least three different metabolic pathways: (i) the dihydroxyacetone kinase (DAK) pathway, (ii) the glycerol (GLD) pathway, and (iii) the fructose-6-phosphate (FSA) pathway. The DAK pathway is named after dihydroxyacetone (DHA) kinase, encoded by the dhaKLM operon. This operon is controlled by DhaR, a transcription factor activated by DHA. DhaKLM is composed of three subunits (DhaK, DhaL, and DhaM) and phosphorylates DHA to dihydroxyacetone phosphate (DHAP), an intermediate in the glycolytic pathway. This kinase resembles a phosphotransferase system (PTS) that uses phosphoenolpyruvate (PEP) as a phosphoryl donor. Experimental and simulated fluxes through DHA metabolism of Escherichia coli, analysis of the metabolic regulation and function of DHA, overview. The DAK pathway is central but not essential for DHA metabolism. The GLD and FSA pathways are functionally involved in DHA metabolism |
-, 758669 |
| 2.7.1.121 | physiological function |
Escherichia coli can metabolize DHA aerobically through at least three different metabolic pathways: (i) the dihydroxyacetone kinase (DAK) pathway, (ii) the glycerol (GLD) pathway, and (iii) the fructose-6-phosphate (FSA) pathway. The DAK pathway is named after dihydroxyacetone (DHA) kinase, encoded by the dhaKLM operon. This operon is controlled by DhaR, a transcription factor activated by DHA. DhaKLM is composed of three subunits (DhaK, DhaL, and DhaM) and phosphorylates DHA to dihydroxyacetone phosphate (DHAP), an intermediate in the glycolytic pathway |
-, 758669 |
