EC Number   |
General Information |
Reference |
|---|
   2.5.1.63 | evolution |
the enzyme belongs to the fluorinases group of the DUF62 enzyme family |
-, 738197 |
| 2.5.1.63 | metabolism |
enzyme NobA shows similar halide specificity and characteristics to the fluorination enzyme FlA of the fl pathway |
-, 738197 |
| 2.5.1.63 | metabolism |
first enzyme in the fluorometabolite pathway to produce the mammalian toxin fluoroacetate and the antibiotic 4-fluorothreonine |
703173 |
| 2.5.1.63 | metabolism |
the enzyme is involved in secondary metabolism, delivering bioactive fluorinated natural products when the bacterium is grown in a medium containing fluoride |
738049 |
| 2.5.1.63 | more |
essential residue S158 of FlA plays critical role in fluoride binding and desolvation |
-, 738197 |
| 2.5.1.63 | more |
essential residue S158 of NbA is required for activity |
-, 738197 |
| 2.5.1.63 | physiological function |
enzyme is essential for fluorometabolite production. Addition of 5'-fluoro-5'-deoxyadenosine to culture broth restores fluorometabolite production in the knockout mutant after a 48 h incubation, consistent with the metabolite supplementation by-passing knockout |
-, 719042 |
| 2.5.1.63 | physiological function |
part of 4-fluorothreonine biosynthesis |
703173 |
