EC Number   |
General Information |
Reference |
|---|
    2.5.1.6 | evolution |
structures of catalytic cycle intermediates of the Pyrococcus furiosus methionine adenosyltransferase demonstrate negative cooperativity in the archaeal orthologues. The distinct molecular mechanism for S-adenosylmethionine synthesis in Archaea is likely consequence of the evolutionary pressure to achieve protein stability under extreme conditions |
-, 759682 |
| 2.5.1.6 | malfunction |
addition of the methionine adenosyltransferase (MAT2A) inhibitor FIDAS to the culture media of bovine preimplantation embryos reduces their blastocyst development |
760152 |
| 2.5.1.6 | malfunction |
depletion of S-adenosylmethionine has downstream effects on polyamine metabolism and methylation reactions, and is an effective way to combat pathogenic microorganisms such as malaria parasites |
759436 |
| 2.5.1.6 | malfunction |
knocking down MAT1A or overexpressing MafG or c-Maf enhances cholangiocarcinoma growth and invasion in vivo |
759323 |
| 2.5.1.6 | malfunction |
mat3 mutants have impaired pollen tube growth and reduced seed set. Metabolomics analyses confirms that mat3 pollen and pollen tubes overaccumulate Met and that mat3 pollen has several metabolite profiles, such as those of polyamine biosynthesis, which are different from those of the wild type. Disruption of Met metabolism in mat3 pollen affects transfer RNA and histone methylation levels |
759977 |
| 2.5.1.6 | malfunction |
mat4 mostly decreases CHG and CHH DNA methylation and histone H3K9me2 and reactivates certain silenced transposons. The exogenous addition of S-adenosyl-L-methionine partially rescues the epigenetic defects of mat4. MAT4 knockout mutations generated by CRISPR/Cas9 are lethal, indicating that MAT4 is an essential gene in Arabidopsis |
759981 |
| 2.5.1.6 | malfunction |
sam1 mutants lose viability during nitrogen starvation-induced G0 phase quiescence. After release from the G0 state, sam1 mutants could neither increase in cell size nor re-initiate DNA replication in the rich medium |
-, 759378 |
| 2.5.1.6 | metabolism |
as a methyl group donor for biochemical reactions, the product S-adenosylmethionine plays a central metabolic role in most organisms |
759436 |
| 2.5.1.6 | metabolism |
methionine adenosyltransferase IIalpha (MAT IIalpha) is a key enzyme in methionine metabolism and is associated with uncontrolled cell proliferation in cancer |
759171 |
| 2.5.1.6 | metabolism |
S-adenosyl-L-methionine (AdoMet) is the primary methyl donor in most biological methylation reactions, is produced from ATP and methionine in a multistep reaction catalyzed by AdoMet synthetase. The diversity of group transfer reactions that involve AdoMet places this compound at a key crossroads in amino-acid, nucleic acid and lipid metabolism |
-, 758605 |
