EC Number   |
General Information |
Reference |
|---|
   2.5.1.148 | evolution |
two SSL cDNAs are identified and named based on the function of their encoded proteins as detailed below: Squalene synthase from race L (LSS) and synthase (LOS). Both the LSS and LOS proteins contain all five conserved activity domains, the transmembrane domain and the NADPH-binding residues found in typical squalene synthase enzymes. As LOS may have arisen from an SS paralogue that evolved to accept GGPP as substrate for lycopaoctaene production, LOS may have retained the ability to use (2E,6E)-farnesyl diphosphate to produce squalene. LSS is a true squalene synthase enzyme, whereas LOS appears to be a promiscuous squalene synthase-like (SSL) enzyme with broader substrate chain length and saturation specificity |
743340 |
| 2.5.1.148 | evolution |
two SSL cDNAs are identified and named based on the function of their encoded proteins as detailed below: Squalene synthase from race L (LSS) and synthase (LOS). Both the LSS and LOS proteins contain all five conserved activity domains, the transmembrane domain and the NADPH-binding residues found in typical squalene synthase enzymes. LSS is a true squalene synthase enzyme, whereas LOS appears to be a promiscuous squalene synthase-like (SSL) enzyme with broader substrate chain length and saturation specificity |
743340 |
| 2.5.1.148 | metabolism |
lycopadiene biosynthesis from C20 prenyl diphosphate intermediates can proceed via two possible biosynthetic routes: the first entails C20 geranylgeranyl diphosphate (GGPP) reduction by GGPP reductase to produce C20 phytyl diphosphate. Two molecules of phythyl diphoshate then undergo head-to-head condensation (1-1' linkage) to produce lycopadiene. The second possibility is the head-to-head condensation of two GGPP molecules to produce lycopaoctaene, followed by stepwise enzymatic reduction to produce lycopadiene |
743340 |
| 2.5.1.148 | metabolism |
the enzyme is involved in biosynthesis of (14E,18E)-lycopadiene. Lycopaoctaene i.e. 15,15'-dihydrophytoene = (6E,10E,14E,18E,22E,26E)-2,6,10,14,19,23,27,31-octamethyldotriaconta-2,6,10,14,18,22,26,30-octaene |
743340, 749460 |
| 2.5.1.148 | more |
there are three different races of Botryococcus braunii based on the hydrocarbons synthesized. Race A produces fatty acid-derived C23-C33 alkadienes and alkatrienes. Races B and L produce isoprenoid-derived hydrocarbons: methylsqualenes and C30-C37 botryococcene triterpenoids in race B and the C40 tetraterpenoid lycopadiene in race L |
743340 |
| 2.5.1.148 | more |
there are three different races of Botryococcus braunii based on the hydrocarbons synthesized. Race A produces fatty acid-derived C23-C33 alkadienes and lkatrienes. Races B and L produce isoprenoid-derived hydrocarbons: methylsqualenes and C30-C37 botryococcene triterpenoids in race B and the C40 tetraterpenoid lycopadiene in race L |
743340 |
| 2.5.1.148 | physiological function |
squalene synthase enzyme diversification results in the production of specialized tetraterpenoid oils in race L of Botryococcus braunii. Race L produces the C40 tetraterpenoid hydrocarbon lycopadiene. trans,trans-Lycopadiene is the predominant hydrocarbon (98% of total hydrocarbons) produced by race L, with a small amount of lycopatriene |
743340 |
| 2.5.1.148 | physiological function |
the enzyme also acts as lycopaoctaene synthase and uses alternative C15 and C20 prenyl diphosphate substrates to produce combinatorial hybrid hydrocarbons, but almost exclusively uses GGPP in vivo, detailed overview. Squalene synthase enzyme diversification results in the production of specialized tetraterpenoid oils in race L of Botryococcus braunii. Race L produces the C40 tetraterpenoid hydrocarbon lycopadiene. trans,trans-Lycopadiene is the predominant hydrocarbon (98% of total hydrocarbons) produced by race L, with a small amount of lycopatriene |
743340 |
