EC Number |
General Information |
Reference |
---|
2.5.1.141 | malfunction |
deletion of the enzyme gene attenuates growth and virulence in mice but enhances pigment production and formation of quinolone tolerant persister cells in stationary phase |
-, 759239 |
2.5.1.141 | malfunction |
without this enzyme, Staphylococcus aureus is repressed in its ability to secrete cytolytic toxins |
-, 743825 |
2.5.1.141 | metabolism |
the enzyme is essential for processing heme into the electron transport chain for use as an electron acceptor |
-, 743825 |
2.5.1.141 | metabolism |
the enzyme plays a role in heme A and heme O synthesis and seems to be required for both cytochrome a and cytochrome o synthesis |
743298 |
2.5.1.141 | metabolism |
the synthesis of the heme a cofactor used in cytochrome c oxidase is dependent on the sequential action of heme o synthase and heme a synthase |
-, 727913 |
2.5.1.141 | physiological function |
the assembly and activity of cytochrome c oxidase is dependent on the availability of heme A, one of its essential cofactors. In eukaryotes, two inner mitochondrial membrane proteins, heme O synthase (Cox10) and heme A synthase (Cox15), are required for heme A biosynthesis. The two physiological partners do not share the same regulatory mechanism. The stoichiometry between Cox15 and Cox10 is 8:1, not 1:1 as it has generally been assumed |
-, 727866 |
2.5.1.141 | physiological function |
the enzyme catalyzes the first step in the conversion of protoheme to the heme A prosthetic groups of the cytochrome c oxidase |
727609 |
2.5.1.141 | physiological function |
the enzyme is involved in persister cell formation under stress and antibiotic treatment |
-, 759239 |