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EC Number General Information Commentary Reference
Show all pathways known for 2.5.1.140Display the reaction diagram Show all sequences 2.5.1.140physiological function during staphyloferrin B biosynthesis, SbnA uses pyridoxal 5'-phosphate and substrates O-phospho-L-serine and L-glutamate to produce a metabolite N-(1-amino-1-carboxyl-2-ethyl)-glutamic acid (ACEGA). SbnB uses NAD+ to oxidatively hydrolyze ACEGA to yield alphaoglutarate and L-2,3-diamnopropionic acid. SbnA and SbnB contribute to the iron sparing response of Staphylococcus aureus that enables staphyloferrin B biosynthesis in the absence of an active tricarboxylic acid cycle -, 740299
Show all pathways known for 2.5.1.140Display the reaction diagram Show all sequences 2.5.1.140physiological function SbnA and SbnB are essential for the synthesis of staphyloferrin B. Supplementation of the growth medium with L-2,3-diaminopropionic acid can bypass the block in staphyloferrin B synthesis displayed by the mutants -, 740234
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