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EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.43malfunction LpxT-dependent lipid A modification is not restored in arnT or eptA mutants 723212
Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.43physiological function ArnT confers resistance to the antibiotic polymyxin in Salmonella typhimurium and Escherichia coli through the modification of lipid A, a major component of the outer surface of Gram-negative bacteria. ArnT transfers a neutral aminoarabinose moiety onto the negative phosphate groups of lipid A, reducing the surface charge of the bacteria and preventing cationic peptides such as polymyxin from electrostatically recognizing and killing the bacteria. Only small amounts of ArnT are necessary to provide resistance against polymyxin to the bacterial cell 702372
Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.43physiological function PmrA controls synthesis of both ArnT and EptA 723212
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