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Results 1 - 3 of 3
EC Number General Information Commentary Reference
Show all pathways known for 2.4.2.10Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.10evolution fusion of the last two enzymes in the pyrimidine biosynthetic pathway in the inversed order by having a C-terminal orotate phosphoribosyltransferase (OPRT) and an N-terminal orotidine 5'-monophosphate decarboxylase (OMPDC), as OMPDC-OPRT, are described in many organisms. During evolution a gene fusion (i.e., the new gene coding for hybrid protein) is the immediate form between a stand-alone gene of a monofunctional enzyme and a gene fission of multienzyme complex (i.e., single gene from multiple smaller coding segments) responsible for protein-protein interaction, in response to different allosteric controls 748831
Show all pathways known for 2.4.2.10Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.10malfunction decreased activity of OPRT plays an important role in the acquired resistance of gastric cancer cells towards 5-fluorouracil. OPRT-knockout MKN-45 parent cells using small interfering RNA demonstrate 15.8fold increased resistance to 5-fluorouracil compared to the control cell 706023
Show all pathways known for 2.4.2.10Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.10physiological function the enzyme is required for mycelial growth, appressorial turgor pressure and penetration into plant tissues, invasive hyphal growth, and pathogenicity -, 735519
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