EC Number |
General Information |
Reference |
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2.4.1.38 | malfunction |
adhesion of blastocysts cells in vitro is greatly inhibited when beta 1,4-GalT-I is blocked with the specific antibody |
719575 |
2.4.1.38 | malfunction |
decreasing the expression of beta1,4GalT V by RNA interference in glioma cells attenuates the formation of polylactosamine and inhibits the ability of tumor formation in vivo. Down-regulation of beta1,4GalT V depletes CD133-positive cells in glioma xenograft, and inhibits the self-renewal capacity and the tumorigenic potential of glioma-initiating cells |
718736 |
2.4.1.38 | malfunction |
gene silencing of isoform beta4GalT5 results in the marked reduction in lactosylceramide synthase activity |
736193 |
2.4.1.38 | malfunction |
knockdown of beta-1,4-GalT-I reduces the activation potentiation caused by the overexpression of CDK11p58, illustrating the function of CDK11p58 to promote astrocyte activation depends on beta-1,4-GalT-I |
719592 |
2.4.1.38 | malfunction |
Lac-Cer synthase activity is significantly decreased in mouse embryonic fibroblast (MEF) derived from beta-1,4-GalT V (B4galt5)-mutant mice, indicating that that murine beta-1,4-GalT V is involved in Lac-Cer biosynthesis |
719573 |
2.4.1.38 | malfunction |
lobe B depletion of the conserved oligomeric Golgi complex severely alters the stability of beta1,4-galactosyltransferase1 (B4GALT1) and alpha2,6-sialyltransferase 1 (ST6GAL1) |
719567 |
2.4.1.38 | malfunction |
overexpression of beta-1,4-GalT-I represses Schwann cell proliferation induced by low concentration of TNF-alpha via ERK1/2 signal pathway and TNFR2, while knocking down beta-1,4-GalT I expression inhibits Schwann cell apoptosis induced by high concentration of TNF-alpha via P38, JNK signal pathways, and TNFR1 |
720448 |
2.4.1.38 | malfunction |
silencing of beta-1,4-GalT I suppresses TNF-alpha autocrine, while overexpression of beta-1,4-GalT I promotes TNF-alpha autocrine in TNF-alpha-treated Schwann cells |
720285 |
2.4.1.38 | malfunction |
the knock-down of the B4GALT1 gene and the inhibition of membrane B4GALT1 function results in the significant inhibition of estrogen-induced proliferation of MCF-7 cells |
718763 |
2.4.1.38 | metabolism |
the isoform beta4GalT6 plays a role as lactosylceramide synthase, while isoform beta4GalT5 acts as a main enzyme for lactosylceramide biosynthesis |
736193 |