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EC Number General Information Commentary Reference
Display the reaction diagram Show all sequences 2.4.1.374physiological function enzyme catalyzes both the sugar nucleotide-dependent biosynthesis and phosphorolytic turnover of mannogen, glycosyltransferase family 108. Isoforms MTP1 and 2 function primarily as GDPMan-dependent beta-1,2-mannosyltransferases. Parasites lacking isoforms Mtp1-7 do not induce lesions or proliferate in highly susceptible BALB/c mice. Expression of MTP1 alone or MTP1/MTP2 together in the absence of phosphorolytic Mtps exacerbates the loss of virulence phenotype, with no recovery of parasites from tissue biopsies. The mutant lacking Mtp2 does not induce lesions in BALB/c mice even when a high inoculum is used 753193
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