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EC Number General Information Commentary Reference
Display the reaction diagram Show all sequences 2.4.1.316physiological function expression of the mycaminosyltransferase TylM2 from Streptomyces fradiae in Saccharopolyspora erythraea SGT2 lacking both eryBV and eryCIII genes encoding the respective glycosyltransferase genes and glycosyltransferase OleG2. Feeding of the resulting strain with the 16-membered aglycone tylactone, the normal TylM2 substrate, leads to formation of a new hybrid glycoside; 5-O-desosaminyl-tylactone 728316
Display the reaction diagram Show all sequences 2.4.1.316physiological function targeted disruption of the gene encoding mycaminosyltransferase does not lead to the accumulation of tylactone under conditions that normally favour tylosin production. Instead, the synthesis of tylactone is virtually abolished. Tylosin production is restored atabout 10% of the wild-type level when othe gene is re-introduced into the disrupted strain. When glycosylated precursors of tylosin are fed to the disrupted strain, they are converted to tylosin, however, tylactone also accumulates under such conditions 728252
Display the reaction diagram Show all sequences 2.4.1.316physiological function the enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin 725186
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