EC Number   |
General Information |
Reference |
|---|
  2.4.1.293 | malfunction |
pglI mutation causes loss of the glucose branch, the Glc transferase mutant pglI/kpsM is still able to synthesize a glycan, structure of the N-linked glycan from the pglI mutant by NMR analysis, overview. The oligosaccharide transferred in the pglI mutant contains the entire 6-mer, demonstrating that Glc plays no role in determining the length of the GalNAc backbone |
-, 719705 |
| 2.4.1.293 | metabolism |
PglI acts in the Campylobacter jejuni N-glycan biosynthesis, it is the glucosyltransferase and the putative ABC transporter, N-glycan pathway, overview |
-, 719705 |
| 2.4.1.293 | metabolism |
PglI is part of a general N-linked glycosylation pathway, encoded by the pgl gene cluster, which culminates in the transfer of a heptasaccharide: GalNAc-alpha1,4-GalNAc-alpha1,4-(Glcbeta1,3)-GalNAc-alpha1,4-GalNAc-alpha1,4-GalNAc-alpha1,3-Bac, where Bac is bacillosamine (2,4-diacetamido-2,4,6-trideoxyglucose), from a membrane-anchored undecaprenyldiphosphate-linked donor to the asparagine side chain of proteins at the Asn-X-Ser/Thr motif. The glycosyltransferases, PglA, PglH, PglI, and PglJ, responsible for the biosynthesis of the undecaprenyl diphoshate-linked heptasaccharide. The final branching glucose is added by PglI, and the flippase, WlaB, then flips the completed lipid-linked heptasaccharide into the periplasm |
-, 720888 |
| 2.4.1.293 | metabolism |
the Pgl pathway produces the N-linked glycan heptasaccharide GalNAc-alpha1,4-GalNAc-alpha1,4-(Glcbeta1,3)-GalNAc-alpha1,4-GalNAc-alpha1,4-GalNAc-alpha1,3-Bac2,4diNAc-1-Asn. The pathway begins with diphosphate bond formation between the Bac2,4diNAc phosphate and undecaprenylphosphate by Cj1124c (PglC) to form Bac2,4diNAc-alpha1-PP-Und. One N-acetylgalactosamine is linked to the polyisoprenediphosphate-bound N,N'-diacetylbacillosamine by Cj1125c (PglA) to form GalNAc-alpha1,3-Bac2,4diNAc-alpha1-PP-Und. Next, four additional GalNAc and one branching glucose are added sequentially to the isoprene-linked disaccharide by PglJ, PglH, and PglI, to form the heptasaccharide, overview |
714160 |
