EC Number   |
General Information |
Reference |
|---|
   2.4.1.214 | malfunction |
suppression of isoform Fut10 expression induces the differentiation of neural stem cells and embryonic stem cells. In addition, enzyme knockdown in the cortical ventricular zone of the embryonic brain impairs the radial migration of neural precursor cells |
736427 |
| 2.4.1.214 | physiological function |
an incomplete down-regulation of FucT activity is sufficient to allow the generation of immunoglobulin Gs carrying a glycan-optimized structure |
694619 |
| 2.4.1.214 | physiological function |
isoform Fut10 is required for the maintenance of stem cell populations. Enzyme overexpression enhances the self-renewal of neural stem cells |
736427 |
| 2.4.1.214 | physiological function |
knocking-out of two XylT genes and four FucT genes in BY-2 suspension cells using CRISPR/Cas9. Three lines show a strong reduction of beta(1,2)-xylose and alpha(1,3)-fucose, while two lines are completely devoid of them, indicating complete gene inactivation. The KO lines do not show any particular morphology and grow as the wild-type. A KO line transformed with genes encoding a human IgG2 antibody shows an IgG2 expression level as high as in a control transformant. The IgG glycosylation profile shows no beta(1,2)-xylose or alpha(1,3)-fucose present on the glycosylation moiety. The dominant glycoform is the GnGn structure |
756828 |
| 2.4.1.214 | physiological function |
overexpression of FUT7 up-regulates sLeX synthesis and enhances sLeX-mediated embryo implantation. FUT7 overexpression enhances JAR cell adhesion to RL95-2 cells |
703774 |
