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Results 1 - 10 of 15 > >>
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.143evolution compared with the structure of human GnTII, the amino acid residues involved in catalytic activity and substrate recognition are almost fully conserved in Bombyx mori GnTII, which is consistent with its enzymatic properties 759523
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.143evolution enzyme TbGT15 belongs to the trypanosome beta3-glycosyltransferase superfamily -, 759473
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.143evolution MGAT2 has been characterized from mammalian, plant, and insect sources, enzyme structure comparisons, overview 760070
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.143malfunction deletion of TbGT15 is accompanied by the absence of complex N-glycans, as well as alterations in the biosynthesis of the giant poly-Lac-dently from prior TbGnTI action, which is in contrast to canonical GnTIIs that only use substrates after modification by GnTI, i.e. Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4GlcNAc -, 759473
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.143malfunction human deficiency in MGAT2 leads to carbohydrate-deficient glycoprotein syndrome type IIa (CDG IIa) characterized by facial dysmorphy, ventricular septal defects, and severely retarded psychomotor development. To date, five MGAT2 mutations have been identified in CDG IIa patients, all residing within the catalytic domain (H262R, S290F, N318D, C339ter, and K237N). Four of the mutations (H262R, S290F, N318D, C339ter) exhibit significantly reduced (compound heterozygote N318D:C339ter) or a complete absence of enzyme activity (H262R, S290F). Three of the residues are nonconserved (H262, N318, and K237), and N318 and K237 H-bond directly or indirectly with the UDP-GlcNAc donor. The S290 is a conserved residue that stabilizes the core of the GT-A fold through H-bonds to peptide bond backbone residues. The H262R, S290F, and K237N mutations break these critical hydrogen bonds and introduce steric clashes to destabilize the protein. The isosteric N318D mutation results in reduced activity similar to the 30 to 37fold reduction in kcat/Km for the N318A 760070
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.143metabolism Asn-linked oligosaccharides are extensively modified during transit through the secretory pathway, first by trimming of the nascent glycan chains and subsequently by initiating and extending multiple oligosaccharide branches from the trimannosyl glycan core. Trimming and branching pathway steps are highly ordered and hierarchal based on the precise substrate specificities of the individual biosynthetic enzymes. A key committed step in the synthesis of complex-type glycans is catalyzed by N-acetylglucosaminyltransferase II (MGAT2), an enzyme that generates the second GlcNAcbeta1,2- branch from the trimannosyl glycan core using UDPGlcNAc as the sugar donor. Enzymatic steps required for the synthesis of the complex-type structures, processing of N-glycans from Man9GlcNAc2 to complex-type structures includes GlcNAc addition by MGAT1, Man trimming by MAN2A1, and GlcNAc addition by MGAT2, pathway overview 760070
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.143metabolism beta-1,2-N-acetylglucosaminyltransferase II is a key enzyme for complex-type N-glycan biosynthesis. Both insect and mammalian cells produce Man(alpha1->6)[GlcNAc(beta1->2)Man(alpha1->3)]Man(beta1->4)GlcNAc(beta1->4)GlcNAc (MGn) glycan as an intermediate during N-glycan processing. In insect cells, beta-N-acetylglucosaminidase (fused lobes, FDL) removes a GlcNAc residue of the alpha1-3 arm of MGn glycan to produce Man(alpha1->6)[Man(alpha1->3)]ManGlcNAc2 (MM), a core structure from paucimannose-type N-glycans 759523
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.143metabolism N-acetylglucosaminyltransferase I or II initiate the elaboration of the Manalpha1-3 and Manalpha1-6 arms, respectively, of the conserved trimannosyl-N-acetylchitobiosyl core of N-linked glycans. Proposed scheme for poly-LacNAc-containing N-glycans of bloodstream form trypanosomes, overview -, 759473
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.143metabolism part of N-glycan pathway 704576
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.143metabolism the enzyme functions at the N-glycan processing branch point and is one of the major factors determining the net outcome of the insect cell N-glycosylation pathway 722801
Results 1 - 10 of 15 > >>