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Results 1 - 6 of 6
EC Number General Information Commentary Reference
Show all pathways known for 2.4.1.135Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.135malfunction dGlcAT-P null mutants larvae show lower expression of glucuronylated T antigen on the muscles and at neuromuscular junctions (NMJs). Mislocalization of NMJ boutons and a partial loss of the basement membrane components collagen IV (Col IV) and nidogen (Ndg) at the muscle 6/7 boundary are observed. The phenotypes correlate to previously described phenotypes in dC1GalT1 mutant larvae. dGlcAT-P null mutants exhibit fewer NMJ branches on muscles 6/7 compared to wild-type. Basement membranes that lack Col IV and Ndg are significantly deformed. The loss of dGlcAT-P expression causes ultrastructural defects in NMJ boutons. Genetic interaction between dGlcAT-P and dC1GalT1 is determined. Phenotypes of dGlcAT-P mutants, detailed overview 759109
Show all pathways known for 2.4.1.135Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.135metabolism genetic interaction between dGlcAT-P and dC1GalT1 (EC 2.4.1.122), and glucuronylated T antigen, rather than unmodified T antigen, contributes to precise localization of NMJ boutons and normal formation of basement membranes on muscles 6/7. Glucuronylated core 1 glycans synthesized by dGlcAT-P are key modulators of neuromuscular junction (NMJ) bouton localization, basement membrane formation, and NMJ arborization on larval muscles. In Drosophila, three major mucin-type O-glycan structures, i.e. Tn antigen (GalNAcalpha1-Ser/Thr), unmodified T antigen (core 1 or Galbeta1-3GalNAcalpha1-Ser/Thr), and glucuronylated T antigen (glucuronylated core 1 or GlcAbeta1-3Galbeta1-3GalNAcalpha1-Ser/Thr), have been reported. And three Drosophila beta1,3-glucuronyltransferases (dGlcATs), dGlcAT-I (DmGlcAT-I), dGlcAT-S (DmGlcAT-BSI), and dGlcAT-P (DmGlcAT-BSII), have been reported in Drosophila. Both dGlcAT-P and dGlcAT-S can transfer GlcA to T antigen in vitro, whereas only dGlcAT-P modifies T antigen in S2 cells 759109
Show all pathways known for 2.4.1.135Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.135metabolism the enzyme is a key regulator and rate-limiting enzyme for the synthesis of GAG chains 721257
Show all pathways known for 2.4.1.135Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.135more gene B3GAT3 is a unigene, pathway enrichment analysis of assembled unigenes, overview. Identification of markers of NK cells. Enzyme structure modelling using the structure of human GlcAT-P as a template 737068
Show all pathways known for 2.4.1.135Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.135physiological function the enzyme mediates a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1, human natural killer-1, also known as CD57, a marker of NK cells 737068
Show all pathways known for 2.4.1.135Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.135physiological function the major components of basement membrane are proteins modified by glycans. In Drosophila, glucuronylation of T antigen is predominantly carried out by Drosophila beta1,3-glucuronyltransferase-P (dGlcAT-P). T antigen formation occurs mainly due to the activity of Drosophila C1GalT1 orthologue 759109
Results 1 - 6 of 6