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EC Number	General Information	Commentary	Reference
2.3.2.B11	physiological function	involved in calcium signalling. The interaction with calmodulin occurs in vivo and depends on physiological concentrations of Ca2+	724178
2.3.2.B11	physiological function	mutating the catalytic cysteine or deleting the entire HECT domain (amino acids 758-1068) results in loss of UBE3B's ubiquitylation activity. Knockdown of UBE3B in human cells induces changes in mitochondrial morphology and physiology, a decrease in mitochondrial volume, and a severe suppression of cellular proliferation	757186

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Release 2023.1 (January 2023)