EC Number   |
General Information |
Reference |
|---|
   2.3.2.32 | malfunction |
down-regulation of RBX1 significantly induces RhoB accumulation and blocks tumor suppressor RhoB degradation in the presence of cycloheximide |
745773 |
| 2.3.2.32 | metabolism |
in the nucleus, SCCRO enhances recruitment of Ubc12 to cullin 1 to promote neddylation. The enzyme facilitates the subcellular localization of neddylation components, which is required for cullin neddylation in vivo |
745283 |
| 2.3.2.32 | metabolism |
Rbx1 acts as the E3 for cullin NEDDylation |
745031 |
| 2.3.2.32 | metabolism |
the enzyme functions as an E3 for related-to-ubiquitin protein modification of cullin 1 |
744783 |
| 2.3.2.32 | metabolism |
the enzyme is an important component of the neddylation E3 complex that functions to recruit charged E2 and is involved in the release of inhibitory effects of CAND1 on cullin-RING ligase E3 complex assembly and activity. The enzyme binds to the components of the neddylation pathway (cullin-ROC1, Ubc12, and CAND1) and augments but is not required for cullin neddylation |
745282 |
| 2.3.2.32 | metabolism |
the function of RBX1 is to bind the ubiquitin-conjugating enzyme E2 and bring it into close proximity with the E3 substrate |
746021 |
| 2.3.2.32 | metabolism |
the Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2 |
745032 |
| 2.3.2.32 | physiological function |
DCNL5 assists Cullin-bound RING-finger protein in neddylation and may be involved in innate immunity. DCNL5 is a direct substrate of the kinase IKKalpha during immune signalling. Upon activation of Toll-like receptors, DCNL5 gets rapidly and transiently phosphorylated on N-terminal serine residue S41. The phosphorylation is specifically mediated by IKKalpha and not IKKbeta |
758171 |
| 2.3.2.32 | physiological function |
overexpression of RBX1 increases protein RUB modification of cullin-1. This effect is associated with reduced auxin response and severe growth defects |
746021 |
| 2.3.2.32 | physiological function |
the enzyme enhances cell proliferation by promoting cullin neddylation |
745283 |
