EC Number   |
General Information |
Reference |
|---|
   2.3.2.23 | evolution |
enzyme UBE2L3 belongs to the E2 family. Humans have around 35 ubiquitin E2 family members, all sharing a core ubiquitin conjugation (UBC) domain that spans roughly 150 residues. E2s are classified by their UBC domain extensions, class I E2s have only the core domain, classes II and III have N- or C-terminal extensions respectively, and class IV are extended at both ends |
758749 |
| 2.3.2.23 | evolution |
enzyme UBE2T belongs to the E2 family. Humans have around 35 ubiquitin E2 family members, all sharing a core ubiquitin conjugation (UBC) domain that spans roughly 150 residues. E2s are classified by their UBC domain extensions, class I E2s have only the core domain, classes II and III have N- or C-terminal extensions respectively, and class IV are extended at both ends |
758749 |
| 2.3.2.23 | evolution |
humans have about 40 E2s that are involved in the transfer of Ub or Ub-like (Ubl) proteins (e.g. SUMO and NEDD8). Common functional and structural features that define unifying themes among E2s, overview. Highly specific chain builders such as Ube2N, Ube2S, and Ube2R1 can only transfer their conjugated Ub to another Ub molecule. This leads to a division of labor among E2s in which one E2 initiates or primes chain synthesis and a second E2 builds and extends the polyUb chain |
759030 |
| 2.3.2.23 | evolution |
humans have about 40 E2s that are involved in the transfer of Ub or Ub-like (Ubl) proteins (e.g., SUMO and NEDD8). Common functional and structural features that define unifying themes among E2s, overview. Highly specific chain builders such as Ube2N, Ube2S, and Ube2R1 can only transfer their conjugated Ub to another Ub molecule. This leads to a division of labor among E2s in which one E2 initiates or primes chain synthesis and a second E2 builds and extends the polyUb chain |
759030 |
| 2.3.2.23 | evolution |
humans have about 40 E2s that are involved in the transfer of Ub or Ub-like (Ubl) proteins (e.g., SUMO and NEDD8). Common functional and structural features that define unifying themes among E2s, overview. Highly specific chain builders such as Ube2N, Ube2S, and Ube2R1 can only transfer their conjugated Ub to another Ub molecule. This leads to a division of labor among E2s in which one E2 initiates or primes chain synthesis and a second E2 builds and extends the polyUb chain. Either Ube2C or a Ube2D family member transfers the first Ub onto human APC/C substrates and Ube2S then builds the K11-linked polyUb chains that are a hallmark of APC/C-mediated proteasomal degradation |
759030 |
| 2.3.2.23 | evolution |
the enzyme belongs to the E2 gene family, phylogenetic analysis of VvUBC family, 43 VvUBC members can be classified into five groups, expression pattern of VvUBCs in different genotypes, detailed overview. Chromosome localization and gene duplication analysis of VvUBCs |
760147 |
| 2.3.2.23 | evolution |
UBE2Z is a 354-residue-long atypical ubiquitin conjugating enzyme comprising about 100-residue long N- and C-terminal extensions on top of the conserved core UBC domain, classifying it as a class IV E2 enzyme |
759478 |
| 2.3.2.23 | evolution |
ubiquitin-conjugating enzyme E2T (UBE2T) is a member of the E2 family that mediates the ubiquitin-proteasome system and regulates gene expression |
760224 |
| 2.3.2.23 | malfunction |
ablation of UBC6e causes upregulation of active ERAD enhancers and so increases clearance not only of terminally misfolded substrates, but also of wild-type glycoproteins that fold comparatively slowly in vitro and in vivo. The absence of UBC6e increases the levels of ERAD enhancers with a corresponding increase in the rate of clearance of misfolded and/or incompletely folded substrates. UBC6e-/- MEFs show accelerated mannose trimming and premature substrate release from CNX, initiated by ER mannosidase-dependent eviction of substrate from the CNX cycle. Finally, by deletion of UBC6e, accelerated degradation is observed in tissue culture and in vivo, not only for canonical ERAD substrates, but also for folding intermediates of proteins that fold slowly, such as tyrosinase. The UBC6e loss-of-function mutation thus produces a gain-of-function with respect to ERAD activity, overview. Increased degradation of tyrosinase in UBC6e-/- cells and reduced skin tyrosinase levels in UBC6e-/- mice |
759764 |
| 2.3.2.23 | malfunction |
backside binding by accessory elements of the RING E3 Rad18 inhibits the intrinsic chain-forming activity of Ube2B, thus promoting monoubiquitylation of PCNA and histone 2B |
759030 |
