EC Number   |
General Information |
Reference |
|---|
    2.3.1.32 | malfunction |
a TgGCN5-A null mutant is deficient in responding to alkaline pH, a common stress used to induce bradyzoite differentiation in vitro. A genome-wide analysis of the Toxoplasma transcriptional response to alkaline pH stress shows that parasites deleted for TgGCN5-A fail to up-regulate 74% of the stress response genes that are induced 2fold or more in wild-type. TgGCN5-A knockout is also incapable of up-regulating key marker genes expressed during development of the latent cyst form, and is impaired in its ability to recover from alkaline stress |
720876 |
| 2.3.1.32 | malfunction |
acetyltransferase-deficient NuA4 mutants have defects in septin collar formation resulting in the development of elongated buds through the Swe1-dependent morphogenesis checkpoint |
720837 |
| 2.3.1.32 | malfunction |
DELTAabl mutants of Methanococcus maripaludis no longer produced Nepsilon-acetyl-beta-lysine and are incapable of growth at high salt concentrations, indicating that the abl operon is essential for Nepsilon-acetyl-beta-lysine synthesis |
657591 |
| 2.3.1.32 | malfunction |
dysfunction is associated with diseases like asthma, cardiovascular disorders, diabetes, and cancer |
704529 |
| 2.3.1.32 | metabolism |
beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) is acetylated in seven lysine residues that face the lumen of the ER and ER Golgi intermediate compartment (ERGIC) |
704532 |
| 2.3.1.32 | physiological function |
Esa1 mediates increased H4 acetylation and enhanced chromatin remodeling complex RSC occupancy and histone eviction in coding sequences and stimulates the rate of transcription elongation by polymerase II |
705700 |
| 2.3.1.32 | physiological function |
specific lysine 158 and lysine 287 acetylation of RIP140 (receptor-interacting protein 140) which is a co-regulator for many transcription factors, acetylation directly enhances the regulator's trans-repressive activity, role in fat accumulation |
703138 |
| 2.3.1.32 | physiological function |
the acetyltransferases cyclic adenosine monophosphate response element-binding binding protein (CBP) and acetyltransferase p300 attenuate transcriptional activity of the mineralocorticoid receptor through its acetylation |
735974 |
| 2.3.1.32 | physiological function |
the enzyme is involved in the biosynthesis of Nepsilon-acetyl-beta-lysine, that is accumulated in the cells to respond to an osmotic upshock |
-, 657591 |
| 2.3.1.32 | physiological function |
transcriptional regulation via histone complex acetylation, possibility of longer chain acyl-CoA transfers is proposed for histone acetyltransferases |
703350 |
